Triterpenoidal saponins of Pulsatilla koreana roots

Yang, Heejung; Cho, Young Woong; Kim, Seung Hyun; Kim, Young Choong; Sung, Sang Hyun

doi:10.1016/j.phytochem.2010.07.013

Cited by 40 publications

(40 citation statements)

References 29 publications

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“…2) characterized by an a-L-arabinopyranose directly branched to the C-3 position were isolated from plants used in traditional Chinese medicine such as S. fagueti (Cioffi et al 2003), S. rotundifolia (Braca et al 2004), P. chinensis (Ye et al 2002) and P. koreana (Bang et al 2005a;Bang et al 2005b). As shown in Table 1, all of these saponins were evaluated in vitro for their cytotoxic activity against several cancer cell lines (A549, SKOV-3, SKMEL2, HCT15, K-562, HeLa and WEHI-164).…”

Section: Pharmacological Activity Of Natural Lupane-type Saponinsmentioning

confidence: 99%

Advances in the synthesis and pharmacological activity of lupane-type triterpenoid saponins

et al. 2010

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Lupeol, betulin and betulinic acid are members of the so-called lupane-type triterpenoids. These natural products found worldwide in quite of lot of vegetables, fruits and plant species exhibit promising pharmacological activities including antiinflammatory, anti-HIV and antitumor activities. Nevertheless, the poor pharmacokinetic properties of these cholesterol-like triterpenoids hampered further pharmaceutical developments. The synthesis of lupanetype saponins, i.e., sugar-derived lupanes, seems to be a good avenue to improve both their water solubility and pharmacological activity. The aims of this review are twofold: first, to describe the biological activity of naturally occurring lupane-type saponins, and second, report the different methodologies employed for the elaboration of glycosidic linkages at the C-3 and/or C-28 positions on the lupane core. The synthesis of both natural and unnatural lupane-type saponins is discussed with an emphasis on molecules exhibiting relevant biological activities.

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Section: Pharmacological Activity Of Natural Lupane-type Saponinsmentioning

confidence: 99%

Advances in the synthesis and pharmacological activity of lupane-type triterpenoid saponins

et al. 2010

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“…The major components of the methanol extract of Pulsatilla koreana are triterpenoid compounds, such as hederagenin, saponins, ursolic acid, monodesmoside (pulsatilla saponin A, B, D), and bisdesmoside (pulsatilla saponin F, H) (8). Those compounds are proposed to be responsible for the major biological functions of Pulsatilla koreana such as lowering blood glucose, cholesterol level and lowering blood pressure (9,10). However, no study has been done to elucidate the plausible mechanism of anti-inflammatory actions of Pulsatilla koreana.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats

Lee

Ko³

2012

BMB Reports

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To investigate the therapeutic effect of a Korean herbal medicine Pulsatilla koreana as an anti-septic agent, anti-inflammatory effects of the herbal medicine were determined in lipopolysaccharide (LPS)-exposed rats. Treatment with a methanol extract from Pulsatilla koreana significantly inhibited LPS-induced inflammatory responses. Results from ELISA analysis showed that Pulsatilla koreana decreased the plasma and hepatic levels of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α while increased the level of anti-inflammatory cytokine IL-10 in LPS-exposed rats. Pulsatilla koreana also decreased the plasma levels of other inflammatory mediators such as NO3

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“…3) In this paper, seven new saponins (1-4, 6-8) and a new lignan glucoside (14) were isolated from the extract of C. barbinervis, together with echinocystic acid 3-β-d-glucuronopyranoside (5), 4) hemsganoside B (9), 5,6) scheffleraside II (10), 5) rotundic acid (11), 7) barbinervic acid (12), 8) clethric acid (13), 9,10) 8-O-4′ neolignan 7-O-β-glucopyranoside (15), 11) rourinoside (16), 12) epicatechin (17), 13) pavetannin A (18), 14) 2-phenylethyl β-glucopyranoside (19), 15) 2-phenylethyl O-α-larabinofuranosyl-(1→ 6)-β-d-glucopyranoside (20), 16) 2-phenylethyl O-α-l-rhamnopyranosyl-(1→ 6)-β-d-glucopyranoside (21), 17) and methyl salicylate β-primeveroside (22) 18) (Figs. 1, 2).…”

mentioning

confidence: 99%

“…Fractions 2A (90.1%, 2.0 mg/mL), 2C (68.0%, 2.0 mg/mL), 2D (78.9%, 2.0 mg/mL), and 2E (71.7%, 2.0 mg/mL) separated from 1C (91.4%, 2.0 mg/mL) had high inhibitory activities. Nine constituents (14)(15)(16)(17)(18)(19)(20)(21)(22) were isolated from 2A, and 17 was active (IC 50 0.94 mm). Catechins are already known to have hyaluronidase inhibitory activity.…”

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confidence: 99%

Triterpene Saponins from <i>Clethra barbinervis</i> and Their Hyaluronidase Inhibitory Activities

et al. 2013

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An extract of Clethra barbinervis with an inhibitory effect on hyaluronidase activity was fractionated guided by the results of an assay. From the active fractions, seven new triterpene saponins (1-4, 6-8) and a new lignan glycoside (14) were isolated together with 14 known compounds (5, 9-13, 15-22). Some of the saponins (2, 3, 9) were revealed as hyaluronidase inhibitors similar to epicatechin (17). Key words Clethra barbinervis; hyaluronidase inhibitor; triterpene saponinHyaluronidase has important roles in the body. It degrades and helps turnover hyaluronic acid in organs and tissues. Moreover, it has been imprecated in inflammatory reactions. Previously, we tested Lamiaceae plant extracts using a hyaluronidase inhibitory assay to identify anti-allergic and antiaging compounds.

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Triterpenoidal saponins of Pulsatilla koreana roots

Cited by 40 publications

References 29 publications

Advances in the synthesis and pharmacological activity of lupane-type triterpenoid saponins

Advances in the synthesis and pharmacological activity of lupane-type triterpenoid saponins

Anti-inflammatory effects of a methanol extract from Pulsatilla koreana in lipopolysaccharide-exposed rats

Triterpene Saponins from <i>Clethra barbinervis</i> and Their Hyaluronidase Inhibitory Activities

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