Triterpenoid saponins of the Caryophyllaceae and Illecebraceae family

Böttger, Stefan; Melzig, Matthias F.

doi:10.1016/j.phytol.2010.08.003

Cited by 67 publications

(25 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The other species belonging to Caryophyllaceae family are rich in oleanolic acid, gypsogenic acid and quillaic acid. The amount of saponins depends on the vegetation period, the part of the plant, and the season (Böttger and Melzig, 2011). The highest concentration of saponins is usually found in the roots or seeds (Kołodziejski and Stecka, 1965).…”

Section: Triterpenoid Saponinsmentioning

confidence: 99%

“…The highest concentration of saponins is usually found in the roots or seeds (Kołodziejski and Stecka, 1965). The dominant class of saponins occurring in this family belongs to the oleanane-type (Böttger and Melzig, 2011). Typical sugar moieties constituting the oleanane-type saponins include apiose, arabinose, fucose, galactose, glucose, glucuronic acid, N-acetyl glucosamine, quinovose, rhamnose, ribose and xylose (Vincken et al, 2007).…”

Section: Triterpenoid Saponinsmentioning

confidence: 99%

See 1 more Smart Citation

Ragged Robin (Lychnis flos-cuculi) - a plant with potential medicinal value

Maliński

Michalska

Tomczykowa

et al. 2014

Revista Brasileira de Farmacognosia

View full text Add to dashboard Cite

Taxonomy Secondary metabolites Biological activity In vitro cultures Micropropagation A B S T R A C T Lychnis flos-cuculi L., Caryophyllaceae, contains a number of active compounds belonging to several chemical groups. Previous studies have led to the identification of phytoecdysteroids, triterpenoids saponins, volatile compounds, fatty acid derivatives, phenolic acids and flavonoids. Research on pharmacological activity showed that plant extracts inhibited the growth of bacteria and fungi. The antimitotic properties of preparations from the herb L. flos-cuculi were also reported. The phytochemical analyses demonstrated that this taxon contains pharmaceutically promising compounds, but more phytochemical and pharmacological studies of L. flos-cuculi are needed for further information regarding this plant. This review summarizes reports regarding chemical composition and biological activity of L. flos-cuculi as well as several cognate species, which pose opportunities related to in vitro propagation and cell and tissue cultures. In vitro-regenerated plantlets could be a good source of genetically uniform plant material for future research.

show abstract

Section: Triterpenoid Saponinsmentioning

confidence: 99%

Section: Triterpenoid Saponinsmentioning

confidence: 99%

Ragged Robin (Lychnis flos-cuculi) - a plant with potential medicinal value

Maliński

Michalska

Tomczykowa

et al. 2014

Revista Brasileira de Farmacognosia

View full text Add to dashboard Cite

show abstract

“…[3] Some of them have and gypsogenic acid as sapogenin. [345678] Triterpenes can be found rarely in the genus and they occur usually as saponins. Only a few have been isolated in native form from the plants of Gypsophila .…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of gypsogenic acid isolated from Gypsophila trichotoma

et al. 2014

View full text Add to dashboard Cite

Background:Gypsophila trichotoma Wend. (Caryophyllaceae) is a medicinal plant which is protected in Bulgaria by the Biodiversity Law. Previous studies have showed the presence of triterpene saponins, sterols, flavonoids, triterpens, etc.Objective:Gypsogenic acid, isolated from Gypsophila trichotoma roots, was evaluated for cytotoxic activity.Materials and Methods:The structure of the compound was elucidated by spectral methods. The cell survival fraction was determined by the MTT dye reduction assay, performed with some modifications.Results:Gypsogenic acid was tested in a panel of human tumor cell lines and was found to inhibit the proliferation of malignant cells. It was active against leukemic cells with lymphoid (SKW-3 and BV-173) or myeloid phenotype (HL-60, K-562, and LAMA-84), as well as against the EJ bladder carcinoma cell line. Bcr-Abl expressing myeloid cells (LAMA-84 and especially K-562) displayed lower sensitivity. HL-60/Dox cells were less sensitive to gypsogenic acid than the parent cell line, which shows that gypsogenic acid is probably a substrate of MRP-1.

show abstract

“…Gypsophila spp., etc. and seeds of Agrostemma githago 8 . The phytoecdysteroids mimics insect molting hormone and strongly interferes with metamorphosis of the insects.…”

Section: Phytochemistry Of the Familymentioning

confidence: 99%