Triterpenes of Lantana tiliaefolia. 24-Hydroxy-3-oxours-12-en-28-oic acid, a new triterpene

Johns, SR; Lamberton, JA; Morton, TC; Suares, H; Willing, RI

doi:10.1071/ch9832537

Cited by 29 publications

(18 citation statements)

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“…Some triterpenes have been isolated from the leaves and stem of L. trifolia (Johns et al, 1983). We report in the present paper the pharmacological activities of the crude extract of L. trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological activities of Lantana trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm

Achola

Munenge

1996

International Journal of Pharmacognosy

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Section: Introductionmentioning

confidence: 99%

Pharmacological activities of Lantana trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm

Achola

Munenge

1996

International Journal of Pharmacognosy

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“…Protein kinase C inhibitor Verbascoside Herbert et al, 1991 4. Anti-inflammatory Oleanolic acid, ursolic acid and Oleanonic acid Hart et al, 1976b;Johns et al, 1983b;Liu, 1995;Verma et al, 1997;Giner-Larza et al, 2001;Benites et al, 2009;Ghosh et al, 2010;Hussain et al, 2011;Sousa & Costa, 2012 5. Antitumor LA, oleanolic acid, ursolic acid, Camaraside and Lantalucratins A-F Brown & Rimington, 1964;Seawright & Hardlicka, 1977;Mahato et al, 1994;Deena & Thoppil, 2000;Ghisalberti, 2000;Hayashi et al, 2004 Brown et al, 1963;Johns et al, 1983a;Singh et al, 1989;Sharma et al 1991;Verma et al, 1997;Wachter et al, 2001;Kong et al, 2006;Verdeguer et al, 2009 9.…”

Section: Toxic Components Of Lantana Camaramentioning

confidence: 99%

“…Antiviral LA, LB, LC, RLA, RLB and 22beta-Hydroxy-3-oxolean-12-en-28-oic acid Johns et al, 1983a;Inada et al, 1995 10. Hepatoprotective Oleanolic acid and ursolic acid Hart et al, 1976b;Johns et al, 1983b;Singh et al, 1990Singh et al, , 1991Liu, 1995;Siddiqui et al, 1995 11. Leukotriene inhibitor Oleanonic acid Hart et al, 1976b;Johns et al, 1983b;Giner-Larza et al, 2001 12.…”

Section: Toxic Components Of Lantana Camaramentioning

confidence: 99%

“…Hepatoprotective Oleanolic acid and ursolic acid Hart et al, 1976b;Johns et al, 1983b;Singh et al, 1990Singh et al, , 1991Liu, 1995;Siddiqui et al, 1995 11. Leukotriene inhibitor Oleanonic acid Hart et al, 1976b;Johns et al, 1983b;Giner-Larza et al, 2001 12. Anti-hyperlipidemic Oleanolic acid and ursolic acid Hart et al, 1976b;Liu, 1995, Liu, 2005Mishra et al, 1997;Verma et al, 1997;Chen et al, 2005 (Lal & Kalra, 1960;Sharma et al, 1988b;Sharma et al, 2007).…”

Section: Toxic Components Of Lantana Camaramentioning

confidence: 99%

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Lantana camara: An alien weed, its impact on animal health and strategies to control

Kumar¹,

Katiyar²,

Kumar³

et al. 2016

JEBAS

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KEYWORDS Lantana camara Lantadenes Allelopathy Hepatotoxic Poisonous ABSTRACTLantana camara is one of the most commonly known noxious weed distributed worldwide. The red flower variety (L. camara var. aculeata) of this weed is mainly toxic and usually prevalent in tropical and sub-tropical countries. Lantana leads to hepatotoxicity, photosensitization and intrahepatic cholestasis almost in all the animals. LA is the main toxic pentacyclic triterpenoid present in this weed. Lantadene toxicity leads to fatty degeneration, bile duct hyperplasia, gall bladder edema, degeneration of parenchymal cells and portal fibrosis observed on histopathological examination. L. camara toxicity causes fluctuation in hematological as well as in biochemical parameters. The management of toxic effects can be achieved by activated charcoal, vaccination and supportive therapy but are not much effective. Besides the harmful effects of this plant, there are some beneficial effects also including antiinflammatory, hepatoprotective action, antitumor action etc. The control of this weed is difficult because of its allelopathic action. Nowadays this plant is used in many recent advanced techniques like phytoremediation of particulate pollution, phytoextraction of heavy metals and many others. Thereby the use of this plant in the field of research can be an effective way to manage this alien weed. As far as the toxicity is concerned it can be prevented by the using conventional therapeutic methods along with immunological, nanotechnological and biotechnological approaches. The aim of this article is to discuss the information regarding its progression, mechanism by which it affect animals, pathological alterations, treatment and what strategies we can opt to get rid of this weed.

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“…Proton ( 1 H NMR), carbon ( 13 C NMR) and (2D-NMR) spectra were compared with those already reported in literature (Ablise et al, 2004;Bruno et al, 1987;Duddeck et al, 1978;Johns et al, 1983;Muhammad et al, 2000;Shibata et al, 1987 100 IU/ml penicillin and 100 μg/ml streptomycin (Roche, Germany) were added to the media.…”

Section: Identification Of Isolated Compoundsmentioning

confidence: 99%

Growth inhibition and induction of apoptosis in human cancerous HeLa cells by Maytenus procumbens

Momtaz¹,

Hussein²,

Ostad³

et al. 2013

Food and Chemical Toxicology

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The possible biochemical activities of the acetonic/ethanolic extract of the leaves of Maytenus procumbens (L.M.P), and its isolated compounds were investigated in the present study. In cytotoxicity assay, L.M.P showed IC 50 of 68.79, 51.22, 78.49, 76.59, and 76.64 µg/ml on Caco-2, HeLa, HT29, NIH3T3, and T47D cells, respectively. Bioassay guided fractionation led to the isolation and identification of a new triterpene: '30-hydroxy-11α-methoxy-18β-olean-12-en-3-one' (HMO) in addition to a known terpenoid: 'asiatic acid' (AA). HMO exhibited the most cytotoxicity against HeLa cells and was further investigated for its ability to induce apoptosis in MTT, Annexin V-fluorescein isothiocyanate; Annexin V-FITC, propidium iodide; PI, radical scavenging capacity; RSC, 1,2-diphenyl-2-picrylhydrazyl; DPPH, ferric-reducing antioxidant power; FRAP, thiobarbituric acid reactive substance; TBARS, reactive oxygen species; ROS, 2,7-dichlorofluorescin diacetate; DCFH-DA.

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Triterpenes of Lantana tiliaefolia. 24-Hydroxy-3-oxours-12-en-28-oic acid, a new triterpene

Cited by 29 publications

References 0 publications

Pharmacological activities of Lantana trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm

Pharmacological activities of Lantana trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm

Lantana camara: An alien weed, its impact on animal health and strategies to control

Growth inhibition and induction of apoptosis in human cancerous HeLa cells by Maytenus procumbens

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