Pharmacological activities of Lantana trifolia on isolated guinea pig trachea and rat phrenic nerve diaphragm

Abstract

A methanol extract of L. trifolia produced bronchodilation of isolated guinea pig trachea comparable to that of salbutamol. The plant extract reduced bronchoconstriction induced by histamine, 5-HT and acetylcholine on isolated guinea pig trachea. Physostigmine failed to inhibit neuromuscular blocking activity of the extract on rat phrenic nerve diaphragm.

Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia

“…From the chemical point of view, there are only a few reports in literature, concerning the composition of its essential oil (Muhayiamana et al, 1998) and the occurrence of a pentamethoxyflavone (umuhengerin) from the leaves, with antibacterial and anti-fungal activities (Rwangabo et al, 1988). Also, pharmacological properties of this plant have not yet been extensively studied, with only one report of its bronchorelaxing activity, similar to that of salbutamol (Achola and Munenge, 1996;Kasonia, 1995). The purpose of the present study is to search for more effective medicinal plants having not only anti-inflammatory activity but also analgesic effects.…”

Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L.

“…is a small shrub that occurs in all regions of Brazil and is extensively used in folk medicine in the form of infusions and syrups for the treatment of respiratory disorders and as sedative (Lorenzi, 2000;Correa, 1926). Few studies have been carried out on either the chemistry or pharmacology (Achola and Munenge, 1996;Silva et al, 2005;Katuura et al, 2007) of this species. Umuhengerin, a pentamethoxyflavone isolated from its leaves, exhibited antibacterial and anti-fungal activities (Rwangabo, 1988), whereas germacrene D and caryophyllene are described as major components of its essential oil (Muhayimana et al, 1998).…”

Chemical composition of the essential oil and hexanic fraction of Lippia and Lantana species

“…Some of the pharmacological properties have been studied including bronchorelaxing (Achola & Munenge, 1996), anti-inflammatory and antinociceptive (Silva et al, 2005), antimycobacterial (Jimenéz-Arellanes et al, 2007), antimicrobial and antimutagenic (Barre et al, 1997;Hernández et al, 2005) and inhibitors of human thrombin activities (O'Neill et al, 1998). Among the species of the genus, the essential oil of the Lantana camara L. is the most studied one (Saleh, 1974;Deena & Thoppil, 2000;Misra & Laatch, 2000;Abdel-Hady et al, 2005;Walden et al, 2009).…”