Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia

Silva, Glauce N.; Martins, Fabíola R.; Matheus, Maria Eline; Leitão, Suzana Guimarães; Fernandes, Patrícia Dias

doi:10.1016/j.jep.2005.02.040

Cited by 85 publications

(60 citation statements)

References 18 publications

(24 reference statements)

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“…Development of oedema induced by carrageenan is commonly correlated with early exudative stage of inflammation (Ozaki 1990, Silva et al 2005. Carrageenan oedema is a multimediated phenomenon that liberates diversity of mediators.…”

Section: Discussionmentioning

confidence: 99%

“…Carrageenan oedema is a multimediated phenomenon that liberates diversity of mediators. It is believed to be biphasic; the first phase (1h) involves the release of serotonin and histamine while the second phase (over 1h) is mediated by prostaglandins, the cyclooxygenase products, and the continuity between the two phases is provided by kinins (Silva et al 2005, Perianayamgam et al 2006. Since carrageenan-induced inflammation model is a significant predictive test for anti-inflammatory agents acting by the mediators of acute inflammation (Mossai et al 1995, Sawadogo et al 2006, the results of this study are an indication that M. discoidea can be effective in acute inflammatory disorders.…”

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo¹,

Sofidiya²,

Afolayan³

2008

RBT

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Abstract:Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. Rev. Biol. Trop. 57 (4): 1193-1200. Epub 2009 December 01.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo¹,

Sofidiya²,

Afolayan³

2008

RBT

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“…The acetic acid-induced writhing was performed using the procedure described by Silva et al [22], with some modifications. In this method, pain-causing acetic acid was injected in the peritoneal cavity, which induced abdominal pain and constrictions (writhing).…”

Section: Evaluation Of the Analgesic Activity Of T Cordifoliamentioning

confidence: 99%

The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

et al. 2015

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“…had significant antiinflammatory effects, inhibiting NO release in the LPS-induced J774. A1 murine macrophage cell line (Julião et al, 2009 Silva et al (2005) studied the antiinflammatory and analgesic activities of L. trifolia L. leaves. ethanol, dichloromethane, ethyl acetate, butanol and aqueous extracts (at 30 mg/kg) inhibited carrageenan-and histamine-induced rat paw edema.…”

Section: Antiinflammatory Analgesic Sedative and Antipyretic Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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Investigation of anti-inflammatory and antinociceptive activities of Lantana trifolia

Cited by 85 publications

References 18 publications

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

The Analgesic, Anti-Inflammatory and Anti-Pyretic Activities of Tinospora cordifolia

Genus Lantana: chemical aspects and biological activities

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