Triterpenes and phenolic compounds isolated from the aerial parts of<i>Herissantia tiubae</i>and evaluation of 5,4′,-dihydroxy-3,6,7,8,3′-pentamethoxyflavone as a modulator of bacterial drug resistance

Silva, Davi Antas e; Falcão-Silva, Vivyanne S.; Gomes, Ana Yara Serrano; Costa, Danielly Albuquerque da; Lemos, Virgı́nia S.; Agra, Maria de Fátima; Braz-Filho, Raimundo; Siqueira-Júnior, José P.; Souza, María de Fátima Vanderlei de

doi:10.1080/13880200802436570

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…Schum.) Brizicky, which contain steroids, phenolic acids, flavonoids, and flavonoid glycosides (Nakatani et al, 1986;Silva et al, 2006;Silva et al, 2009) and Gossypium arboreum L., which contains flavonoid glycosides (Bakoma et al, 2013) The results of the present study demonstrated that 25 mg/kg of W. periplocifolia CEE produced antiinflammatory activity comparable to that of indomethacin. However, this effect was not CEE dose-dependent.…”

Section: Discussionsupporting

confidence: 50%

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl (jangadeira)

Guedes¹,

Ramalho²,

Ramalho³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Wissadula periplocifolia (L.) C. Presl is a plant of the Malvaceae family that is popularly known as white velvet leaf ("jangadeira" and "malva-malva" in Brazil). Species of this family are used in folk medicine as diuretic, anti-inflammatory and anti-rheumatic agents. This study evaluated the acute toxicity and anti-inflammatory effects of a crude ethanolic extract of W. periplocifolia. Acute toxicity testing revealed reduced food intake and decreased serum creatinine and alkaline phosphatase levels in males, as compared to the control group, suggesting a loss of muscle mass. Assessment of antiinflammatory activity using a rat paw carrageenan-induced edema model showed that 25 mg/kg of this ethanolic extract significantly reduced edema, although this was not observed at higher doses. These findings indicated that this W. periplocifolia extract was non-toxic and had some anti-inflammatory effects. However, a more comprehensive assessment is necessary to evaluate other possible indicators of toxicity, particularly during chronic administration.

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Section: Discussionsupporting

confidence: 50%

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl (jangadeira)

Guedes¹,

Ramalho²,

Ramalho³

et al. 2016

Afr. J. Pharm. Pharmacol.

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“…The first phytochemical investigations of H. tiubae resulted in the isolation of several classes of compounds, including kaempferol glycosides (Silva et al, 2004), triterpenes (Silva et al, 2008) and polyoxygenated/polymethoxylated flavones (Silva et al, 2005(Silva et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

Modulation of drug resistance in staphylococcus aureus by a kaempferol glycoside from herissantia tiubae (malvaceae)

Falcão-Silva¹,

Silva²,

Souza³

et al. 2009

Phytotherapy Research

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In an ongoing project to evaluate natural compounds isolated from plants from the Brazilian biodiversity as modulators of antibiotic resistance, kaempferol-3-O-beta-d-(6''-E-p-coumaroyl) glucopyranoside (tiliroside), isolated from Herissantia tiubae (Malvaceae) was investigated using the strain SA-1199B of Staphylococcus aureus, which overexpresses the norA gene encoding the NorA efflux protein which extrudes hydrophilic fluorquinolones and some biocides, such as benzalkonium chloride, cetrimide, acriflavine and ethidium bromide. The minimum inhibitory concentrations (MICs) of the antibiotics and biocides were determined by the microdilution assay in the absence and in the presence of sub-inhibitory concentration of tiliroside. Although tiliroside did not display relevant antibacterial activity (MIC = 256 microg/mL), it modulated the activity of antibiotics, i.e. in combination with antibiotics a reduction in the MIC was observed for norfloxacin (16-fold), ciprofloxacin (16-fold), lomefloxacin (four-fold) and ofloxacin (two-fold), and an impressive reduction in the MICs for the biocides (up to 128-fold). The results presented here represent the first report of a kaempferol glycoside as a putative efflux pump inhibitor in bacteria. The present finding indicates that H. tiubae (and broadly Malvaceae) could serve as a source of plant-derived natural products that modulate bacterial resistance, i.e. a source of potential adjuvants of antibiotics.

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“…For the evaluation of mesoionics as modulators of drug resistance, “modulation assay” was used, a method that has been widely applied to identify potential EPIs, and is valid provided one uses specifically known effluxing strains. The MICs of the antibiotics were determined in the presence of the mesoionic compound at a sub-inhibitory concentration [ 33 , 34 , 35 ].…”

Section: Methodsmentioning

confidence: 99%

Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds

et al. 2011

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Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold.

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Triterpenes and phenolic compounds isolated from the aerial parts ofHerissantia tiubaeand evaluation of 5,4′,-dihydroxy-3,6,7,8,3′-pentamethoxyflavone as a modulator of bacterial drug resistance

Cited by 14 publications

References 33 publications

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl (jangadeira)

Preclinical assessment of the acute toxicity and anti-inflammatory activity of Wissadula periplocifolia (L.) C. Presl (jangadeira)

Modulation of drug resistance in staphylococcus aureus by a kaempferol glycoside from herissantia tiubae (malvaceae)

Drug Resistance Modulation in Staphylococcus Aureus, a New Biological Activity for Mesoionic Hydrochloride Compounds

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