Triterpene Saponins from Polygalaceae

Lacaille‐Dubois, Marie‐Aleth; Mitaine-Offer, Anne Claire

doi:10.1007/s11101-005-2606-6

Cited by 33 publications

(24 citation statements)

References 39 publications

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“…However, reports have shown that polygalasaponins could be toxic to animals, leading to nose bleeding, gastrointestinal tract abnormality, and even death (Xue et al, 2009;Lin et al, 2012), which seriously limits their application and development. Recently, researchers have found that the hydrolysate of polygalasaponin (HPS) could attenuate or abrogate the toxicity (Lacaille-Dubois and Mitaine-Offer, 2005). This makes HPS a better choice in dementia treatment.…”

Section: Introductionmentioning

confidence: 99%

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

Wang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Objectives: The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polygalasaponin (HPS) on senescence accelerate mouse P8 (SAMP8) mice, an effective Alzheimer's disease (AD) model, and to research the relevant mechanisms. Methods: The cognitive-enhancing effects of HPS on SAMP8 mice were assessed using Morris water maze (MWM) and step-through passive avoidance tests. Then N-methyl-D-aspartate (NMDA) receptor subunit expression for both the cortex and hippocampus of mice was observed using Western blotting. Results: HPS (25 and 50 mg/kg) improved the escape rate and decreased the escape latency and time spent in the target quadrant for the SAMP8 mice in the MWM after oral administration of HPS for 10 d. Moreover, it decreased error times in the passive avoidance tests. Western blotting showed that HPS was able to reverse the levels of NMDAR1 and NMDAR2B expression in the cortex or hippocampus of model mice. Conclusions: The present study suggested that HPS can improve cognitive deficits in SAMP8 mice, and this mechanism might be associated with NMDA receptor (NMDAR)-related pathways.

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Section: Introductionmentioning

confidence: 99%

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

Wang

et al. 2016

J. Zhejiang Univ. Sci. B

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“…They were reported to significantly affect cancer cell growth and have therefore incited considerable interest of many researchers. Recent reviews have been published focusing on isolation, structure elucidation, biological activities of triterpenoids (Mahato and Sen 1997;Tan et al 1999;Connolly and Hill 2000;Sparg et al 2004;Lacaille-Dubois and Mitaine-Offer 2005;Park et al 2005;Piacente et al 2005;Lanzotti 2005), biosynthesis (Henry 2005;Szakiel et al 2005), classification, and occurrence of saponins (Vincken et al 2007), but no exclusive research work is done on AATS and informations on these molecules are dispersed in the available literature.…”

Section: Introductionmentioning

confidence: 99%

A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

et al. 2011

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“…Triterpene glycosides are good candidates for this purpose due to their aglycon bearing various glycosidic moieties, from a single sugar to an oligosaccharide chain, as mono or bidesmosidic structures. Many of these compounds have been isolated and characterized during the last decades [15,16]. Herein we report the selection of isolated natural triterpene glycosides as structures bearing different glycosyl moieties and their immunochemical characterization in MS patientsʼ sera.…”

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confidence: 99%

Natural Triterpene Glycosides for Antibody Recognition

et al. 2016

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!Multiple sclerosis is an autoimmune disease that affects the central nervous system. The key role of the glycosylation in disease pathogenesis has been previously studied and the synthetic Nglucosylated peptide CSF114(Glc) proved its efficiency in autoantibody recognition in the sera of multiple sclerosis patients. Herein, pure natural triterpene glycosides containing different glycosyl moieties were isolated and tested in multiple sclerosis patientsʼ sera to better understand the role of glycosylation. They were selected taking into account the nature and complexity of their osidic part. Five triterpene glycosides were isolated from several plants with more than 95% purity. The interaction between these glycosides and autoantibodies was evaluated in an enzyme-linked immunosorbent assay measuring IgG and IgM levels in multiple sclerosis patients and healthy blood donors, and the results were compared with those of CSF114(Glc). For each antigen, Mann Whitney and receiver operating characteristic-based analysis were performed to evaluate any statistical significance of the results. The five natural triterpene glycosides showed good capacity to recognize IgMs (sensitivity up to 38 %) with a high specificity (88.9%) for multiple sclerosis patients.Key words multiple sclerosis · triterpene glycosides · autoimmune disease · biomarkers · autoantibody recognition Supporting information available online at http://www.thieme-connect.de/products Complex glycoconjugates, including glycolipids and glycoproteins, are commonly displayed on cell surfaces, where they play crucial roles as intermediaries in extracellular communication and signalling networks [1][2][3]. Therefore, studies on glycan modification patterns of glycoconjugates are a great challenge in medical diagnostic research, offering insight into cellular molecular mechanisms. Moreover, glycoconjugates can be proposed as molecular biomarkers for the disease activity [4,5]. In the field of autoimmunity, different approaches are used to investigate the structures and functions of complex naturally occurring glycoconjugates leading to the identification of autoantigens associated with different autoimmune diseases. In particular, in the context of multiple sclerosis (MS), the development of serum antibodies as biomarkers to be used for the diagnosis, monitoring, and prognosis of such a heterogeneous disease is a challenge because of the ambiguous identification of antigens (Ags) implicated in the disease. MS pathogenesis has not been yet elucidated but includes viral, immunological, and vascular hypotheses [6]. Most of the putative Ags belong to the myelin protein family (i.e., myelin basic protein, proteolipid lipoprotein, and myelin oligodendrocyte glycoprotein). Moreover, pathophysiological post-translational modifications of native Ags can trigger the immune system to generate autoantibodies escaping conventional diagnostic procedures [7]. Thus, autoantibodies against aberrant glycosylations have been hypothesized as diagnostic biomarkers in MS [8,9]. I...

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Triterpene Saponins from Polygalaceae

Cited by 33 publications

References 39 publications

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

Natural Triterpene Glycosides for Antibody Recognition

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