A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

Abstract

The aim of this review is to highlight updated results on the biologically active saponins from Leguminosae-Mimosoideae. Acacic acid-type saponins (AATS), is a class of very complex glycosides possessing a common aglycon unit of the oleanane-type (acacic acid = 3b, 16a, 21b trihydroxy-olean-12

Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells

“…In addition, the 1 H NMR spectrum of 2 exhibited two olefinic proton signals at d Acacic acid-type saponins have been reported to exhibit cytotoxic activity on various tumor cell types, namely human Jurkat leukemia cells, cutaneous lymphoma cells, breast, ovarian and pancreatic tumors. 2 To address the cytotoxic activity of these our Table 2 1 H NMR (500 MHz) and 13 C NMR (125 MHz) data of the monoterpene-quinovosyl moieties attached at C-21 of compounds 1-2 in pyridine-d 5 new acacic acid glycosides, lebbeckosides A (1) and B (2), we evaluated their activity on cancer stem-like cells isolated from glioblastoma which correspond to high grade human brain tumors, with very poor prognosis and for which there is an unmet medical need. Brain tumors, like many other tumors contain cancer stem-like cells, 24,25 known for their implication in tumor fueling, resistance to chemotherapies and tumor recurrence after therapy.…”

“…6 Previous phytochemical studies of A. lebbeck stem bark reported the presence of glycosides of acacic acid lactones. 7 In the present investigation on A. lebbeck roots, we report the isolation and structural characterization of two new acacic acid glycosides, named lebbeckosides A-B (1)(2). The isolated compounds were evaluated for their inhibitory effect on the http://dx.doi.org/10.1016/j.carres.2014.12.004 0008-6215/Ó 2014 Elsevier Ltd. All rights reserved.…”

“…Adianthifoliosides, grandibracteosides, gummiferaosides, julibrosides, coriariosides, and albizosides are complex triterpenoid saponins isolated from the Albizia genus. 2 These glycosides, represent a class of very complex glycosides possessing a common aglycon unit, acacic acid, having various oligosaccharide moieties at C-3 and C-28 and an acyl group at C-21. They have been reported to inhibit the growth of tumor cells, and thus appear as a new potential class of anticancer natural triterpenoid saponins.…”

“…They have been reported to inhibit the growth of tumor cells, and thus appear as a new potential class of anticancer natural triterpenoid saponins. 2 In order to discover new bioactive acacic acid glycosides, we screened the saponin content of Cameroonian Mimosaceae including Albizia, Acacia, and Entada genera. Three Albizia species, among which Albizia lebbeck, were selected on the basis of their HPLC-DAD, LC-NMR, and LC-MS profiles.…”

Anti-proliferative effect of Flos Albiziae flavonoids on the human gastric cancer SGC-7901 cell line

“…Mounting evidence indicates a possible role of biologically active flavonoids against many organ cancers. Human epidemiological trials have revealed an association between intake of flavonoids and reduced risk of cancer, including gastric cancer (1–7). …”