Triterpene glycosides of the flowers ofCephalaria kotschyi

Aliev, A. M.; Movsumov, I. S.

doi:10.1007/bf00566362

Cited by 7 publications

(7 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previously described monoterpene alkaloids [5,6] were considered artefacts formed by the chemical transformation of iridoids by the ammonia solution used for the extraction. …”

supporting

confidence: 87%

Iridoid glycosides from Cephalaria kotschyi roots

Mustafaeva

Élias²,

Balansard³

et al. 2008

Chem Nat Compd

View full text Add to dashboard Cite

“…Previously described monoterpene alkaloids [5,6] were considered artefacts formed by the chemical transformation of iridoids by the ammonia solution used for the extraction. …”

supporting

confidence: 87%

Iridoid glycosides from Cephalaria kotschyi roots

Mustafaeva

Élias²,

Balansard³

et al. 2008

Chem Nat Compd

View full text Add to dashboard Cite

“…Finally, they were analyzed by 1 H NMR and HR ESIMS methods. Alkaline hydrolysis of 1, 2, and 3 afforded three known triterpene glycosides which were also isolated in this study, namely, macranthoside A (10) [24], α-hederin (8) [22], and sapindoside B (9) [23], respectively.…”

Section: Alkaline Hydrolysismentioning

confidence: 97%

“…Since this extract showed antimicrobial activity, we decided to make a phytochemical examination of its BuOH fraction. As a result, three new hederagenin type triterpene glycosides (1)(2)(3), named elmalienoside A-C, together with nine known natural compounds, macranthoidin A (4) [18], dipsacoside B (5) [19], 3-Oα-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester (6) [20] [22], sapindoside B (9) [23], macranthoside A (10) [24], tiliroside (11) [25], and luteolin 7-O-β-D-glycoside (12) [26], were isolated from the aerial parts of C. elmaliensis. The structures of these compounds were identified by extensive spectroscopic analysis, including 1D, 2D NMR, HR ESIMS data, and chemical evidence.…”

mentioning

confidence: 99%

“…5) [19], 3-O-α-L-rhamnopyranosyl-(1 → 2)α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester (6) [20], and 3-O-β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl-(1 → 2)-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester (7)[21]. The monodesmosidic ones were elucidated as α-hederin (8)[22], sapindoside B (9)[23], and macranthoside A (10)[24]…”

mentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobially Active Hederagenin Glycosides from Cephalaria elmaliensis

Sarikahya

Kirmizigul

2012

Planta Med

View full text Add to dashboard Cite

A phytochemical investigation of the aerial parts of Cephalaria elmaliensis resulted in the isolation of ten hederagenin-type triterpene saponins (1-10) including three new ones, elmalienoside A (1), elmalienoside B (2), elmalienoside C (3), and two known flavonoid glycosides (11-12). Their structures were identified by extensive spectroscopic techniques (1D and 2D NMR, HR ESIMS) and chemical evidence. The antimicrobial activity of the extracts and the pure compounds was evaluated by the MIC method. According to the results, all pure compounds including the new ones were found to be very active against both gram-positive and gram-negative bacteria.

show abstract

“…The structures of the isolated compounds were determined using one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy ( 1 H, 13 C, heteronuclear single quantum coherence [HSQC], heteronuclear multiple bond correlation [HMBC], and correlation spectroscopy [COSY]). The sapogenins, pomolic acid (1) 13 and tormentic acid (2), 14 10 known triterpene saponins, namely elmalienosides A and B (3 and 4), 11 davisianosides A and B (5 and 6), 6 α-hederin (7), 15 16 3 17 dipsacoside B (10), 18 macranthoidin A (11), 19 and 3-O-α-l-rhamnopyranosyl-(1→3)-β-dglucopyranosyl hederagenin (12), 20 and 1 iridoid glycoside, namely laciniatoside I (13) 21 were obtained. Among these compounds pomolic acid (1), tormentic acid (2), and 3-O-α-lrhamnopyranosyl-(1→3)-β-d-glucopyranosyl hederagenin (12) were detected in the genus Cephalaria and the family Caprifoliaceae, for the first time.…”

mentioning

confidence: 99%

Comparative Phytochemical Screening and Cytotoxic Efficacy of Endemic Cephalaria tuteliana

Dagli

Sarikahya

Nalbantsoy

et al. 2019

Natural Product Communications

View full text Add to dashboard Cite

Phytochemical investigation of Cephalaria tuteliana (Caprifoliaceae) endemic to Turkey was carried out for the first time. Thirteen compounds were isolated, including 2 triterpenoid sapogenins, 10 saponins, and 1 iridoid glycoside. This is the ﬁrst report of the isolation of pomolic acid, tormentic acid, and 3- O-α-l-rhamnopyranosyl-(1→3)- β-d-glucopyranosyl hederagenin, not only from the Cephalaria genus, but also from the Caprifoliaceae family. The structures of the isolated compounds were elucidated by a combination of spectroscopy, including one- and two-dimensional nuclear magnetic resonance, and by comparison with the reported data in the literature. Two triterpene sapogenins, hederagenin and oleanoic acid, the latter being the most typical sapogenin of the oleanane type of triterpene saponins, were evaluated by the MTT method for their cytotoxic effect against A549, HeLa, PANC1, and SHSY5Y cancer cells, and the noncancerous HEK293 cell line. The cytotoxic activity of triterpene aglycones was discussed in detail and a structure-activity relationship was established. C. tuteliana may be considered as a useful source for developing new cytotoxic and immunotherapeutic agents due to its biologically active saponin content.

show abstract

Triterpene glycosides of the flowers ofCephalaria kotschyi

Cited by 7 publications

References 1 publication

Iridoid glycosides from Cephalaria kotschyi roots

Iridoid glycosides from Cephalaria kotschyi roots

Antimicrobially Active Hederagenin Glycosides from Cephalaria elmaliensis

Comparative Phytochemical Screening and Cytotoxic Efficacy of Endemic Cephalaria tuteliana

Contact Info

Product

Resources

About