Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization

Umeyama, Akemi; Yahisa, Yoshinori; Okada, Minori; Okayama, Eriko; Uda, Ayaka; Shoji, Noboru; Lee, Je‐Jung; Takei, Masao; Hashimoto, Toshihiro

doi:10.1007/s11418-010-0438-1

Cited by 11 publications

(6 citation statements)

References 10 publications

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“…Kurosengoku (Kurosengoku) extracts trigger the production of IL-12 from DCs mediated by TLR4 and TLR2 and sequentially induced IFN-γ production [ 29 ]. Triterpene esters, uncarinic acid C (1) and uncarinic acid D (2) obtained from the hooks of Uncaria rhynchophylla were found to activate cytokine production of human DCs towards Th1 [ 30 ]. Also, purified galactomannan from Caesalpinia spinosa induced phenotypic maturation in monocyte-derived DCs (MDDCs) revealed by increased expression of maturation markers, reduced antigen uptake, and increased protein and mRNA levels of proinflammatory cytokines [ 31 ].…”

Section: Modulation Of DC Activitiesmentioning

confidence: 99%

Modulation of dendritic cell immune functions by plant components

Aldahlawi

2016

J Microsc Ultrastruct

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Dendritic cells (DCs) are the key linkage between innate and adoptive immune response. DCs are classified as specialized antigen-presenting cells that initiate T-cell immune responses during infection and hypersensitivity, and maintain immune tolerance to self-antigens. Initiating T-cell immune responses may be beneficial in infectious diseases or cancer management, while, immunosuppressant or tolerogenic responses could be useful in controlling autoimmunity, allergy or inflammatory diseases. Several types of plant-derived components show promising properties in influencing DC functions. Various types of these components have been proven useful in clinical application and immune-based therapy. Therefore, focusing on the benefits of plant-based medicine regulating DC functions may be useful, low-cost, and accessible strategies for human health. This review illustrates recent studies, investigating the role of plant components in manipulating DC phenotype and function towards immunostimulating or immunosuppressing effects either in vitro or in vivo.

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Section: Modulation Of DC Activitiesmentioning

confidence: 99%

Modulation of dendritic cell immune functions by plant components

Aldahlawi

2016

J Microsc Ultrastruct

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“…The butanol fraction of the stems and leaves of Echinacea purpurea significantly influences BMDC maturation and T-cell proliferation [29]. It has been observed that uncarinic acid C, uncarinic acid D, and triterpene esters isolated from Uncaria rhynchophyla plants were found to activate cytokine production of human DCs towards Th1 immune responses [48].…”

Section: Activation Of T-cellsmentioning

confidence: 99%

Dendritic Cells (DCs)-Based Cancer Immunotherapy: A Review on the Prospects of Medicinal Plants and Their Phytochemicals as Potential Pharmacological Modulators

Munaz

Uddin²,

Hossen

et al. 2022

Applied Sciences

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Dendritic cells (DCs) are specialized antigen-presenting cells in humans and animals that provide antigen-specific T-cell immunity in the body. It also establishes a linkage between innate and adaptive immune responses. Various studies have shown that malignancies or cancer may impair DCs and effector T-cell functions. DCs have now become a new molecular target for the treatment of cancer. Modified matured DCs could be novel biological modifiers to treat various diseases, including cancer. This review aims to provide an update on the impacts of various plant materials and their phytochemicals on DC-based cancer immunotherapy. Existing literature on DC-based cancer immunotherapy and plant-based pharmacological modulators has been explored over the last decade using various online databases such as Google Scholar, PubMed, Science Direct, and Scopus. Mounting evidence from preclinical and clinical findings suggests that various plants and their bioactive phytochemicals are effective in modulating the immune system and signaling pathways involved in anti-tumor immunity. Despite the prospective role of herbs in DC-based cancer immunotherapy, most of the studies are limited by either preclinical models or crude plant extracts. This review provides a useful perspective for developing potential plant-derived pharmacological modulators in DC-based cancer immunotherapy.

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“…Por otro lado, también se mejoró la actividad de los LT CD8 + cuando estos se enfrentaron a líneas celulares tumorales, induciendo en estas últimas la muerte por apoptosis (68) . Un extracto hidroalcohólico de Uncaria rhynchophylla, rico en ácido uncarinico C y D (0,01-0,1mM), mejoró la expresión de CD1a, CD80, CD83, CD86 y HLA-DR en DC de origen humano (69,70) .…”

Section: Efectos Inmunomoduladores De Plantas Medicinales Sobre Célulunclassified

Inmunoterapia en melanoma: vacunas de células dendríticas

Lozada-Requena

Núñez²,

Aguilar

2015

Rev Peru Med Exp Salud Publica

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La presente es una revisión narrativa que muestra la información accesible a la comunidad científica sobre melanoma e inmunoterapia. Las células dendríticas tienen la capacidad de participar en la inmunidad innata y adaptativa, pero no son ajenas a la evasión inmune de los tumores. Conocer su biología y rol ha llevado a generar in vitro varios prospectos de vacunas celulares autólogas contra diversos tipos de cáncer en humanos y modelos animales; sin embargo, en vista de la poca eficiencia que han mostrado, se deben implementar estrategias para potenciar su capacidad natural ya sea a través de la coexpresión de moléculas clave para activar o reactivar al sistema inmune, en combinación con biosimilares o drogas quimioterapeúticas y no se debe descartar la acción de productos naturales como alternativa inmunoestimulante o adyuvante. Todos los tipos de inmunoterapía deberían medir el impacto de las células supresoras de origen mieloide, las que pueden atacar al sistema inmune y ayudar a la progresión tumoral, respectivamente. Esto puede reducir la actividad de las vacunas celulares y/o sus combinaciones pudiendo ser la diferencia entre el éxito o no de la inmunoterapia. Aunque en melanoma existen biosimilares aprobados por la Food and Drug Administration (FDA) no todos tienen el éxito esperado por lo que es necesario evaluar otras estrategias que incluyan vacunas celulares cargadas con péptidos antigénicos tumorales expresados exclusivamente o antígenos provenientes de extractos tumorales y sus respectivos adyuvantes.

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Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization

Cited by 11 publications

References 10 publications

Modulation of dendritic cell immune functions by plant components

Modulation of dendritic cell immune functions by plant components

Dendritic Cells (DCs)-Based Cancer Immunotherapy: A Review on the Prospects of Medicinal Plants and Their Phytochemicals as Potential Pharmacological Modulators

Inmunoterapia en melanoma: vacunas de células dendríticas

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