Modulation of dendritic cell immune functions by plant components

Abstract

Dendritic cells (DCs) are the key linkage between innate and adoptive immune response. DCs are classified as specialized antigen-presenting cells that initiate T-cell immune responses during infection and hypersensitivity, and maintain immune tolerance to self-antigens. Initiating T-cell immune responses may be beneficial in infectious diseases or cancer management, while, immunosuppressant or tolerogenic responses could be useful in controlling autoimmunity, allergy or inflammatory diseases. Several types of plant-derived components show promising properties in influencing DC functions. Various types of these components have been proven useful in clinical application and immune-based therapy. Therefore, focusing on the benefits of plant-based medicine regulating DC functions may be useful, low-cost, and accessible strategies for human health. This review illustrates recent studies, investigating the role of plant components in manipulating DC phenotype and function towards immunostimulating or immunosuppressing effects either in vitro or in vivo.

Induction of Antitumor Immunity by Exosomes Isolated from Cryopreserved Cord Blood Monocyte-Derived Dendritic Cells

“…In this study, DCs were successfully generated from cryo CB in culture medium containing GM-CFS, IL-4, and TNF-α, which consistently showed a DC marker expression profile, such as CD80high, CD86high, CD40high, HLA-DRhigh, CD123low CD56low, and CD14low. Cryo CBMDCs expressed a typical DC morphology with thin and long dendrites, which have been described in previous reports [21,22,[26][27][28][29][30]. Thus, our results indicate that cryo CB can be a potential source for DC generation, which then may be developed into immunotherapies.…”

The Difference of Integrin ανβ3 Expression, Leukemia Inhibitory Factors and Superoxide Dismutase Serum Concentration in the Provision of Kebar Extract (Biophytum petersianum Klotczh), Metformin, and Their Combination to Mouse models of Endometriosis

“…2,25 According to several studies, Biophytum petersianum Klotzsch is able to induce especially the activation of dendritic cells and also the response to T cells, B cells, and NK cells related to the role of saponin content in inducing the production of cytokines, interleukins, and interferons. 15,26 The effect of Biophytum on apoptosis as an anti-tumor based on the previous research was gotten by regulating Bcl-2, Caspase-3 and p-53 genes and the production of inflammatory cytokines and tumor activated macrophage. 25,27 Saponin extract of in vitro studies used human endometrial stromal cells from post-surgical patients with a diagnosis of endometriosis and it was known to able to induce apoptosis in endometrial cells through the modulation of miR-21-5p.…”

Immunostimulant plant proteins: Potential candidates as vaccine adjuvants

“…The immune‐modulating effects of astragalus root and elderberry fruit extracts were examined in bone marrow‐derived murine DCs. The ELISA and RT‐PCR tests indicated that both extracts enhanced IFN‐ß production, increased endocytosis in immature DCs, upregulated toll‐like receptor 3, and enhanced the IL‐12, IL‐6, IL‐1b, and TNFα cytokines release (Aldahlawi, 2016 ). Also, induction, maturation, and differentiation of DCs were reported by Mucuna pruriens extract (Kurokawa et al, 2011 ).…”

“…Also, induction, maturation, and differentiation of DCs were reported by Mucuna pruriens extract (Kurokawa et al, 2011 ). The Abelmoschus esculentus increased the expression of IL‐12, interferon IFNγ, and stimulated DCs by modulating the expression of class II‐MHC and costimulatory CD + 80/86 molecules (Aldahlawi, 2016 ; Sheu & Lai, 2012 ).…”