Trisomy 21 is associated with hypercholesterolemia during intrauterine life

Bocconi, Luisa; Nava, S.; Fogliani, Roberto; Nicolini, Umberto

doi:10.1016/s0002-9378(97)70544-1

Cited by 33 publications

(22 citation statements)

References 11 publications

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“…Functional network analyses in this study also related dysfunction of cholesterol metabolism to trisomy 21 (Table 3), which agreed with previous reports that DS fetuses have an intrinsic lipid metabolism abnormality (25,26,41,42). Lower levels of apolipoprotein A1 have been noted in DS patients compared with normal controls, resulting in a lower ratio of apolipoprotein A1 to B (25,26).…”

Section: Use Of Metacore For Biologic Network Analysis On a Group Of supporting

confidence: 91%

Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes

Wang

Chao

Chen

et al. 2009

Fertility and Sterility

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Section: Use Of Metacore For Biologic Network Analysis On a Group Of supporting

confidence: 91%

Network analyses of differentially expressed proteins in amniotic fluid supernatant associated with abnormal human karyotypes

Wang

Chao

Chen

et al. 2009

Fertility and Sterility

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“…DS fetuses were also found to have increased TC and increased apolipoprotein A levels compared with controls. 28 Another possible mechanism for increased dyslipidemia in children with DS involves leptin, a hormone secreted by adipose tissue that correlates with percentage of fat mass in humans. 29 In a previous study, we found that children with DS had increased leptin levels for percentage of body fat when compared with their siblings, suggesting increased leptin resistance at the same fat level with DS.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profiles of Children With Down Syndrome Compared With Their Siblings

Adelekan¹,

Magge

Shults

et al. 2012

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Some researchers have suggested that individuals with Down syndrome (DS) are protected from atherosclerotic disease; however, recent data from 2 large cohort studies of individuals with DS are significant for increased mortality from ischemic heart disease and cerebrovascular disease. WHAT THIS STUDY ADDS:This study compares lipid profiles among children with DS and their siblings, highlighting the presence of a less favorable lipid profile in this high-risk population.abstract OBJECTIVES: Our objective was to compare serum lipid profiles, total cholesterol (TC), low-density lipoprotein (LDL), triglycerides (TG), and high-density lipoprotein (HDL) between children with Down syndrome (DS) and their non-DS siblings. We hypothesized that the children with DS would have higher TC, LDL, and TG and lower HDL. The secondary aim was to explore if the difference in lipid profiles could be explained by differences in weight status.METHODS: This was a cross-sectional study. Fasting lipid profile was obtained from 27 children with DS and 31 siblings between 4 and 10 years of age with no severe comorbidities (heart disease, cancer, hypothyroidism, diabetes, or obesity). BMI was calculated and BMI z scores were used to account for differences in BMI throughout childhood.RESULTS: Children with DS had higher TC (difference, 11.2 mg/dL; 95% confidence interval: 2.5-19.9; P = .01), LDL (12.8 mg/dL; 7.2-18.4; P , .001), TG (33.6 mg/dL; 11.1-56.1; P = .003), and lower HDL (27.6 mg/dL; 212.1 to 23.0; P = .001) after adjustment for race, gender, age, and ethnicity. Results remained significant after additional adjustment for BMI z score: TC (14.9 mg/dL; 4.9-24.9; P = .003), LDL (16.6 mg/dL; 10.1-23.2; P , .001), TG (32.7 mg/dL; 7.7-57.7; P = .01), and lower HDL (26.4 mg/dL; 212.2 to 20.7; P = .03).CONCLUSIONS: Children with DS have less favorable lipid profiles than their siblings independent of weight status. These findings may have important implications for the screening and treatment of this large population at increased risk for ischemic heart disease. Pediatrics

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“…Bocconi et al studied lipid metabolism in DS and showed that trisomy 21 is associated with hypercholesterolaemia during the intrauterine life 6. Its relation with the increased prevalence of cholelithiasis in the first two years of life requires further study.…”

Section: Discussionmentioning

confidence: 99%