2007
DOI: 10.1002/ajp.20424
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Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis

Abstract: Trisomy 13 in humans is the third most common autosomal abnormality at birth, after trisomy 21 and trisomy 18. It has a reported incidence of between 1:5,000 and 1:30,000 live births. It is associated with multiple abnormalities, many of which shorten lifespan. We describe here the first reported case of a baboon (Papio hamadryas) with trisomy of chromosome 17, which is homologous to human chromosome 13. The trisomic infant was born to a consanguineous pair of baboons and had morphological characteristics simi… Show more

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Cited by 15 publications
(8 citation statements)
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“…Mortality resulting from nephritis/glomerulonephritis (n = 22) was generally seen in aged (11,50.0%) and adult (7, 31.8%) baboons with a 3:1 female to male ratio. Animals with nephritis/glomerulonephritis-related mortality were more likely to have been euthanized (19,86.4%) than to have died.…”
Section: Urogenital Systemmentioning
confidence: 99%
“…Mortality resulting from nephritis/glomerulonephritis (n = 22) was generally seen in aged (11,50.0%) and adult (7, 31.8%) baboons with a 3:1 female to male ratio. Animals with nephritis/glomerulonephritis-related mortality were more likely to have been euthanized (19,86.4%) than to have died.…”
Section: Urogenital Systemmentioning
confidence: 99%
“…The only study of aneuploidy in nonhuman primate oocytes involved five younger and seven older animals in which 4 out of 30 oocytes were aneuploid [54]. There are 15 cases of autosomal trisomies reported in nonhuman primates [16,31,42,52].…”
Section: Maternal Age Weight and Paritymentioning
confidence: 99%
“…The differential diagnosis for a finding of NTD with associated defects such as omphalocele and heart defects includes chromosomal abnormalities, such as trisomy 13 or 18, and single gene mutations leading to conditions such as Meckel syndrome. Because the macaque and human genomes are quite similar, human probes can be utilized to diagnose primate chromosomal aneuploidies [Best et al, 1998; Moore et al, 1999, 2007]. Although metaphase chromosomes were not obtained from culture of the infant's skin and muscle because of lack of growth from the decomposed tissue, the results of the microarray analysis using human probes effectively eliminated aneuploidy, or any copy number changes greater than approximately 3–5 Mb, as a cause of the malformations.…”
Section: Discussionmentioning
confidence: 99%