Trisomy 17 in a baboon (<i>Papio hamadryas</i>) with polydactyly, patent foramen ovale and pyelectasis

Moore, Charleen M.; Hubbard, Gene B.; Dick, Edward J.; Dunn, Betty G.; Raveendran, Muthuswamy; Rogers, Jeffrey; Williams, Vick; Gomez, Jeremiah J.; Butler, Stephanie D.; Leland, M. Michelle; Schlabritz‐Loutsevitch, Natalia

doi:10.1002/ajp.20424

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…Mortality resulting from nephritis/glomerulonephritis (n = 22) was generally seen in aged (11,50.0%) and adult (7, 31.8%) baboons with a 3:1 female to male ratio. Animals with nephritis/glomerulonephritis-related mortality were more likely to have been euthanized (19,86.4%) than to have died.…”

Section: Urogenital Systemmentioning

confidence: 99%

Mortality in captive baboons (Papio spp.): a‐23‐year study

Dick

Owston

David

et al. 2014

J of Medical Primatology

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Background We report the causes of mortality for 4,350 captive baboons that died or were euthanized due to natural causes during a 23 year period at the Southwest National Primate Research Center. Methods Necropsy records were retrieved and reviewed to determine a primary cause of death or indication for euthanasia. Data was evaluated for morphological diagnosis, organ system and etiology. Results The 20 most common morphologic diagnoses accounted for 76% of the cases, including: stillborn (10.8%); colitis (8.6%); hemorrhage (8.4%); ulcer (5.2%); seizures (4.7%); pneumonia (4.2%); inanition (4.1%); dermatitis (3.8%); spondylosis (3.3%); and amyloidosis (3.0%). The digestive system was most frequently involved (21.3%), followed by the urogenital (20.3%), cardiovascular (12.2%), and multisystem disease (10.3%). An etiology was not identified in approximately one third of cases. The most common etiologies were trauma (14.8%), degenerative (9.5%), viral (8.7%), and neoplastic/proliferative (7.0%). Conclusion This information should be useful for individuals working with baboons.

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Section: Urogenital Systemmentioning

confidence: 99%

Mortality in captive baboons (Papio spp.): a‐23‐year study

Dick

Owston

David

et al. 2014

J of Medical Primatology

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“…The only study of aneuploidy in nonhuman primate oocytes involved five younger and seven older animals in which 4 out of 30 oocytes were aneuploid [54]. There are 15 cases of autosomal trisomies reported in nonhuman primates [16,31,42,52].…”

Section: Maternal Age Weight and Paritymentioning

confidence: 99%

The baboon model (Papio hamadryas) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome

Schlabritz‐Loutsevitch

Moore

López-Alvarenga

et al. 2008

J of Medical Primatology

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Background Several risk factors are associated with the incidence of human stillbirths. The prevention of stillbirths in women is a pressing clinical problem. Methods We reviewed 402 pathology records of fetal loss occurring in a large baboon (Papio spp.) colony during a 15-year period. Clinical histories of 565 female baboons with one or more fetal losses during a 20-year period were analyzed for weight, age, and reproductive history. Results Fetal loss was most common at term (35.57%) and preterm (28.61%) and less common in the first half of gestation (11.20%) and post-term (5.22%). Greater maternal weight, older age, history of stillbirth and higher parity were independent predictors for stillbirth. An exponential increase in the incidence of fetal loss was observed beginning at age 14 years in baboons. Conclusion Fetal loss and maternal risk factors associated with stillbirths in baboons were similar to those documented in women.

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“…The differential diagnosis for a finding of NTD with associated defects such as omphalocele and heart defects includes chromosomal abnormalities, such as trisomy 13 or 18, and single gene mutations leading to conditions such as Meckel syndrome. Because the macaque and human genomes are quite similar, human probes can be utilized to diagnose primate chromosomal aneuploidies [Best et al, 1998; Moore et al, 1999, 2007]. Although metaphase chromosomes were not obtained from culture of the infant's skin and muscle because of lack of growth from the decomposed tissue, the results of the microarray analysis using human probes effectively eliminated aneuploidy, or any copy number changes greater than approximately 3–5 Mb, as a cause of the malformations.…”

Section: Discussionmentioning

confidence: 99%

Craniorachischisis and omphalocele in a stillborn cynomolgus monkey (Macaca fascicularis)

Moore

Dick

Hubbard

et al. 2011

American J of Med Genetics Pt A

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Nonhuman primates have been a common animal model to evaluate experimentally-induced malformations. Reports on spontaneous malformations are important in determining the background incidence of congenital anomalies in specific species and in evaluating experimental results. Here we report on a stillborn cynomolgus monkey (Macaca fascicularis) with multiple congenital anomalies from the colony maintained at the Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, Texas. Physical findings included low birth weight, craniorachischisis, facial abnormalities, omphalocele, malrotation of the gut with areas of atresia and intussusception, a Meckel diverticulum, arthrogryposis, patent ductus arteriosus, and patent foramen ovale. The macaque had normal male external genitalia, but undescended testes. Gestational age was unknown but was estimated from measurements of the limbs and other developmental criteria. Although cytogenetic analysis was not possible due to the tissues being in an advanced state of decomposition, array Comparative Genomic Hybridization analysis using human bacterial artificial chromosome clones was successful in effectively eliminating aneuploidy or any copy number changes greater than approximately 3–5 Mb as a cause of the malformations. Further evaluation of the animal included extensive imaging of the skeletal and neural tissue defects. The animal’s congenital anomalies are discussed in relation to the current hypotheses attempting to explain the frequent association of neural tube defects with other abnormalities.

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Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis

Cited by 15 publications

References 25 publications

Mortality in captive baboons (Papio spp.): a‐23‐year study

Mortality in captive baboons (Papio spp.): a‐23‐year study

The baboon model (Papio hamadryas) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome

Craniorachischisis and omphalocele in a stillborn cynomolgus monkey (Macaca fascicularis)

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