The baboon model (<i>Papio hamadryas</i>) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome

Schlabritz‐Loutsevitch, Natalia; Moore, Charleen M.; López-Alvarenga, Juan Carlos; Dunn, Betty G.; Dudley, Donald J.; Hubbard, Gene B.

doi:10.1111/j.1600-0684.2008.00297.x

Cited by 35 publications

(41 citation statements)

References 54 publications

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“…The pathological conditions associated with obesity in the human population are insulin resistance, hyperlipidemia, and risk of stillbirth. The same associations have been also found in baboons [20, 21, 44]. The incremental differences of body fat content between obese and non-obese baboons are close to those seen in humans [18].…”

Section: Discussionsupporting

confidence: 74%

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Feto-placental Adaptations to Maternal Obesity in the Baboon

et al. 2009

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Maternal obesity is present in 20-34% of pregnant women and has been associated with both intrauterine growth restriction and large-for-gestational age fetuses. While fetal and placental functions have been extensively studied in the baboon, no data are available on the effect of maternal obesity on placental structure and function in this species. We hypothesize that maternal obesity in the baboon is associated with a maternal inflammatory state and induces structural and functional changes in the placenta. The major findings of this study were 1) decreased placental syncytiotrophoblast amplification factor, intact syncytiotrophoblast endoplasmic reticulum structure and decreased system A placental amino acid transport in obese animals; 2) fetal serum amino acid composition and mononuclear cells (PBMC) transcriptome were different in fetuses from obese compared with non-obese animals 3) maternal obesity in humans and baboons is similar in regard of increased placental and adipose tissue macrophage infiltration, increased CD14 expression in maternal PBMC and maternal hyperleptinemia. In summary, these data demonstrate that in obese baboons in the absence of increased fetal weight, placental and fetal phenotype are consistent with those described for large-for-gestational age human fetuses.

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Section: Discussionsupporting

confidence: 74%

“…Another non-human primate species, the baboon, has been extensively studied as a model for obesity [18, 19]. Increased weight in this species has been associated with insulin resistance [20] and stillbirth [21]. These data are in agreement with the published human data.…”

Section: Introductionsupporting

confidence: 74%

Feto-placental Adaptations to Maternal Obesity in the Baboon

et al. 2009

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“…Baboons have already been used on a wide variety of reproductive studies, including pregnancy [40, 41, 42, 43,] fetal development [44, 45,] pharmacokinetics of compounds in pregnancy [46, 47,] abortifactant drugs [48,]nutrient restriction and the maternal/fetal relationship [49,] genetics [50,] endometriosis [51, 52,] hormonal [14, 16, 21, 53, 54, 55, 56,] temporary contraception [57, 58,] embryonic stem cells and ART [13,] pathology [59, 60,] and permanent contraception [18.] Their temperament and similarities to human anatomy warrant their continued use for reproductive studies.…”

Section: Discussionmentioning

confidence: 99%

The baboon (Papio sp.) as a model for female reproduction studies

Bauer¹

2015

Contraception

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Due to their size and anatomical similarity to humans, baboons make an excellent model for reproductive studies. Baboons have a simple short cervix, muscular uterus, ovaries just lateral to the uterus, and similar vasculature to that of humans. Because of the size of the animals, instruments designed for use in women can be readily used on baboons. Noninvasive determination of phase of estrous cycle is readily made by observation of changes in perineal sexual skin turgor and color. Some advantages of use of baboons compared to other nonhuman primates is that they are non-seasonal breeders, allowing for studies to be conducted year-round, have minimal infectious disease risks to humans as they do not carry Herpes B, and have a social structure allowing for easy group formation. Baboons serve as good models for many conditions in humans and should be considered for studies investigating reproductive issues.

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“…The first day of pregnancy was estimated as the day a female’s sexual swelling began to decrease minus two days (26). In cases where the cycle data were not available, pregnancy was dated by ultrasound examination under sedation.…”

Section: Methodsmentioning

confidence: 99%

Abruptio placentae in the baboon (Papio spp.)

Schenone

Schlabritz‐Loutsevitch

Zhang

et al. 2012

Placenta

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Introduction Placental abruption is a serious condition that increases perinatal morbidity and mortality. Clinical prevention and treatment options are limited, especially in human preterm deliveries. Knowledge of the mechanisms that keep the placenta in place during pregnancy is critical for developing strategies for the prevention of abruption. Failure of physiological transformation of spiral arteries has been described as a major contributing factor of the placental abruption development. Baboons (Papio spp.) share striking similarities with humans in regard to placental structure, utero-placental blood flow, and fetal development; however, the mode of trophoblast invasion is shallow in baboons. This fact prompted the hypothesis that the incidence of placental abruption will be increased in baboons compared to humans. Material and methods Baboon placentas were collected between 2002 and 2008. Two independent veterinary pathologists evaluated the slides. A certified physician pathologist performed additional histology. Results Placental abruption was diagnosed in 22 baboons among 2,423 live births during the study period (0.9% prevalence). The most common clinical presentations were fetal demise and vaginal bleeding. The most common pathological findings were intraplacental hemorrhage with or without hematoma formation (86.4%). Other findings consisted of neutrophil infiltration (50%), decidual necrosis (22.7%), decidual vascular congestion and inflammation, villous congestion and retroplacental hemorrhage/hematoma (18.2%). These pathologic findings were the same for term and preterm deliveries. Conclusion This is the first systematic study of placental abruption in non-human primates, analyzing a large colony of baboons. Despite differences in trophoblast invasion, the clinical features observed in placental abruption affecting baboons resembled those reported in humans. The cluster of placental pathological findings in baboons also agreed with clinical reports, but the prevalence of these findings differed between baboons and humans. We discuss a mechanism of anti-abruption forces that offset shallow trophoblast invasion observed in baboons.

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The baboon model (Papio hamadryas) of fetal loss: maternal weight, age, reproductive history and pregnancy outcome

Cited by 35 publications

References 54 publications

Feto-placental Adaptations to Maternal Obesity in the Baboon

Feto-placental Adaptations to Maternal Obesity in the Baboon

The baboon (Papio sp.) as a model for female reproduction studies

Abruptio placentae in the baboon (Papio spp.)

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