Triptolide affects the differentiation, maturation and function of human dendritic cells

Effects of vasoactive intestinal peptide on phenotypic and functional maturation of dendritic cells

“…On stimulation by microbial products, inflammatory cytokines, or CD40 ligation, DC differentiate into T-cell-stimulatory cells [19]. Maturation is associated with increase of surface MHC, T-cell adhesion, and co-stimulatory (CD40, CD80, CD86, CD54) molecules, with an ability to secrete proinflammatory cytokines and IL-12p70, and induce proliferation of T cells [20].…”

The immunoregulatory effects of Chinese herbal medicine on the maturation and function of dendritic cells

“…It is well known DCs play important roles in the development of autoimmune diseases and GVHD. The inhibitory effects of triptolide on the maturation and function of DCs have been investigated (Chen et al, 2005;Liu et al, 2007;Zhu et al, 2005). Triptolide prevented the differentiation of DC from monocytes by inhibiting CD1a, CD40, CD80, CD86 and HLA-DR expression, suppressed the LPS-induced maturation of Mo-DCs by blocking CD83 expression and suppressing up-regulation of CD40, CD80, CD86 and HLA-DR, and reduced the capacity of Mo-DC to stimulate lymphocyte proliferation in the allogeneic MLR (Zhu et al, 2005).…”

“…The inhibitory effects of triptolide on the maturation and function of DCs have been investigated (Chen et al, 2005;Liu et al, 2007;Zhu et al, 2005). Triptolide prevented the differentiation of DC from monocytes by inhibiting CD1a, CD40, CD80, CD86 and HLA-DR expression, suppressed the LPS-induced maturation of Mo-DCs by blocking CD83 expression and suppressing up-regulation of CD40, CD80, CD86 and HLA-DR, and reduced the capacity of Mo-DC to stimulate lymphocyte proliferation in the allogeneic MLR (Zhu et al, 2005). Another study showed that triptolide treatment not only inhibited the DC maturation and IL-12 production but also decreased the calcium mobilization and chemotactic responses of LPSstimulated DCs to secondary lymphoid tissue chemokine (SLC)/CC chemokine ligand 21 (CCL21) compared to untreated DCs, in association with lower CCR7 and higher CCR5 expression (Chen et al, 2005).…”

Innovative Topical Formulations for Treatment of Dermatitis

“…Nowadays, it is widely used for treatment of psoriasis and atopic dermatitis [80]. The transdermal delivery and anti-inflammatory activity was evaluated by Mei et al [81] using triptolide-loaded SLN and microemulsion.…”