Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative caucasian patients with ankylosing spondylitis

Yabuki, Kazuro; Ôta, Masao; Goto, Kaori; Kimura, Tamon; Nomura, Eiich; Ohno, Shigeaki; Mizuki, Nobuhisa; Katsuyama, Yoshihiko; Makysymowych, W.P; Bahram, Seiamak; Kimura, Minoru; Inoko, Hidetoshi

doi:10.1016/s0198-8859(98)00092-5

Cited by 39 publications

(22 citation statements)

References 14 publications

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“…This increase was not confirmed when B27 positive patients and controls were compared. We showed that it was due to the linkage disequilibrium found between pairs MIB-6 HLA-B27 and MICA-A4 and HLA-B27 (Table 3), already reported by others [12,13], although it is not significant for HLA-B27 and D6S273-4.…”

Section: Microsatellite Allelic Frequenciessupporting

confidence: 69%

HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in basque patients

Juan¹,

Reta²,

Belzunegui³

et al. 2004

Human Immunology

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Section: Microsatellite Allelic Frequenciessupporting

confidence: 69%

HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in basque patients

Juan¹,

Reta²,

Belzunegui³

et al. 2004

Human Immunology

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“…The MIC-A gene has already been found to confer genetic risk for Behçet's disease [27,28] and ankylosing spondylitis [29]. We have recently shown additionally that the MIC-A5.1 allele is statistically significantly increased in patients with autoimmune Addison's disease and that this association is not due to a linkage disequilibrium with HLA class II genes [30].…”

mentioning

confidence: 70%

Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes

et al. 2000

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Type I (insulin-dependent) diabetes mellitus is an autoimmune disease characterised by the presence of circulating islet autoantibodies and by T-lymphocyte infiltration of the islets of Langerhans with consequent destruction of pancreatic beta cells [1]. A permissive genetic background is required for the development of the islet autoimmune process. Type I diabetes is a complex genetic disease and a long series of genes has been found to be linked with disease Diabetologia (2000) Methods. Type I diabetic (n = 95) and healthy (n = 98) Italian subjects were typed for exon 5 of MIC-A and for HLA-DRB1, HLA-DQA1, HLA-DQB1 and TNFA alleles. All subjects were also typed for the presence of HLA-B8 or HLA-B15.Results. The frequency of MIC-A5 was increased in diabetic subjects (53 % vs 15 %) (OR = 6.1) (corrected p, p c < 0.0005). Among HLA class II haplotypes, both HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) (ªat-risk class II haplotypesº) were positively associated with diabetes (OR = 6.7 and 6.0, respectively) (p c < 0.003). Also HLA-B8 was more frequent among Type I diabetic subjects than among healthy control subjects (OR = 2.8, p = 0.01). None of the TNFA alleles were statistically significantly associated with Type I diabetes. The MIC-A5 exon was negatively associated with age at clinical onset of diabetes (p = 0.012). Thus, 68 % diabetic subjects younger than 25 years and 29 % older than 25 years were carrying this allele. Both MIC-A5 and the at-risk class II haplotypes were independently associated with Type I diabetes and the combined association of the two markers had the highest relative risk (OR = 172). In subjects younger than 25 years, the OR of MIC-A5 was as high as 21.7 and was more than twofold that of at-risk class II haplotypes (OR = 9.5). The MIC-A5 exon was not in linkage disequilibrium with any of the HLA-class I, class II or TNFA alleles studied. Conclusions/interpretation. The MIC-A gene polymorphism is associated with genetic risk for Type I diabetes and the combination of MIC-A5 and at-risk class II haplotypes is now to be seen as the strongest genetic marker for this disease. [Diabetologia (2000) 43: 507±514]

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“…We found that the frequency of MICA*A4 allele was elevated in seropositive RA patients. MICA*A4 has previously been demonstrated to be associated with many autoimmune diseases, such as, ankylosing spondylitis [3,4], IDDM [17], celiac disease [22], HLA-B27 associated uveitis [24], and juvenile idiopathic arthritis [8]. However, in the case of ankylosing spondylitis, linkage disequilibrium with HLA-B27 and MICA was reported [25].…”

Section: Discussionmentioning

confidence: 99%

“…Although the role of MICA is not entirely clear, its localization in the human leukocyte antigen region and its reaction with ␥␦ T cells and natural killer cells suggest the association with autoimmune disease [2]. The (GCT)n microsatellite polymorphisms in the transmembrane region of MICA consists of four (A4), five (A5, A5.1), six (A6), and nine (A9) triplet GCT repeats, which have been reported to be associated with many autoimmune diseases, including several arthritis syndromes (such as, spondylitis, Behcet's disease, psoriatic arthritis, and juvenile idiopathic arthritis) [3][4][5][6][7][8]. In addition, Singal et al and Martinez et al recently demonstrated that the MICA allele 6 might be a protective genetic marker in Caucasian RA patients [9,10].…”

Section: Introductionmentioning

confidence: 99%

Association of MICA polymorphism with rheumatoid arthritis patients in Koreans

Mok¹,

Lee²,

Kim³

et al. 2003

Human Immunology

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Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative caucasian patients with ankylosing spondylitis

Cited by 39 publications

References 14 publications

HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in basque patients

HLA-A*2402 and a microsatellite (D6S248) are secondary independent susceptibility markers to ankylosing spondylitis in basque patients

Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes

Association of MICA polymorphism with rheumatoid arthritis patients in Koreans

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