Association of MICA polymorphism with rheumatoid arthritis patients in Koreans

Genetic Polymorphisms of TLR4 and MICA are Associated with Severity of Trachoma Disease in Tanzania

“…In this study, MIC-A9 allele was found to be more frequent in the healthy subjects, which indicates a protective role. Mok et al [39] reported on a possible protective role of MICA-A9 in the susceptibility to rheumatoid Arthritis in Korean subjects. Also, It has previously been reported that the MICA-A9 allele might confer protection from IDDM and celiac disease in the Spanish population [40,41].…”

Predisposition to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A

“…The ITP susceptibility region seemed to be located in the surroundings of the STR-MICA locus, indicating class I centromeric region, at the end of the ␤ block, as a primary predisposing region. Previous studies have indicated STR-MICA associated with rheumatoid arthritis (weak association with MICA*04, secondary to HLA-DRB1*0405 association, and weak protective effect associated with MICA*09 in Koreans [22]), psoriatic arthritis (disease development associated with MICA*09, the same MICA*002 allele), and BehÈet's disease (associated with STR-MICA*06 in the absence of HLA-B*51 [15]). Those results indicate that the MICA gene may be involved in autoimmune diseases etiology, including ITP.…”

Higher risk of cytomegalovirus reactivation in human immunodeficiency virus–1–infected patients homozygous for MICA5.1

“…Several studies have shown that MICA microsatellite alleles were associated with several autoimmune diseases, including celiac disease [30] and rheumatoid arthritis [31]. However, less is known about the impact of MICA alleles on viral infections.…”