Predisposition to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A

Maia, María Helena Thomaz; Peixoto, Raquel de Lima; Lima, Clayton Pereira Silva de; Magalhães, Milena; Sena, Leonardo; Costa, Perpétua do Socorro Silva; Barbosa, Fabíola Brasil; Oliveira, Layanna Freitas de; Romero, Matilde; Silva, Christina Nogueira de Araujo; Santos, Eduardo José Melo dos

doi:10.1016/j.humimm.2009.01.011

Cited by 17 publications

(6 citation statements)

References 34 publications

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“…This result may highlight the putative functional role of MHC class I polypeptide-related sequence A (MICA) in the immune response to ITP [8]. Hence, according to a case-control study conducted with an aim to map the MHC to ITP susceptibility using HLA-B and nine microsatellite loci encompassing MHC class I, II, and III regions in samples of unrelated healthy controls and ITP patients, only allele MICA Ã 183 demonstrated an association, resulting in the identification of a major predisposing region close to STR-MICA.…”

Section: Discussionmentioning

confidence: 89%

Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura

Bay

Coşkun²,

Öztuzcu

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

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Immune thrombocytopenic purpura (ITP) is a commonly acquired autoimmune bleeding disorder in children. MicroRNAs (miRNAs) are small RNAs which are found in cells and circulation, and play a role in protein synthesis and regulation. In this study, we aimed to determine a biomarker for childhood ITP comparing the plasma miRNA levels of children having ITP with healthy children. A total of 86 patients with ITP and 56 healthy children followed up by the Department of Pediatric Hematology and Oncology in University of Gaziantep since July 2011 were enrolled in the study. The 86 patients with ITP were evaluated in two groups as 43 acute ITP (aITP) and 43 chronic ITP (cITP) patients. Plasma expression levels of 379 miRNAs were investigated by RT-PCR (quantitative RT-PCR) technique and they were compared between aITP, cITP, and control groups. For all miRNAs, the average of raw quantification cycle values of three groups separately in the analysis chip was accepted as the reference gene value, and normalization was done according to this value. Statistically significant differences were detected in seven miRNAs (miR-302c-3p, miR-483-5p, miR-410, miR-544a, miR-302a-3p, miR-223-3p, and miR-597) investigated between the groups with respect to the expression levels. The expression rates were found to be over 95% in miR-302c-3p and miR-483-5p, over 75% in miR-410, and over 40% in miR-544, miR-302a-3p, and miR-223-3p in all three groups. The detection of significant differences between plasma miRNA levels of aITP and cITP patients and healthy children may provide useful information in the prediction of the course of disease, determination of disease etiopathogenesis, and the development of new therapeutic modalities.

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Section: Discussionmentioning

confidence: 89%

Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura

Bay

Coşkun²,

Öztuzcu

et al. 2014

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

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“…Moreover, Maia et.al . (66) concluded that susceptibility to autoimmune thrombocytopenic purpura (ITP) relates with genes located very close to MICA or even MICA itself ( Supplementary Figure 6, B ). Furthermore, MICA has an abnormal expression on granulocytes of PNH patients (67) ( Supplementary Figure 6, C ).…”

Section: Discussionmentioning

confidence: 99%

Visualization and Analysis of the Interaction Network of Proteins Associated with Blood-cell targeting Autoimmune Diseases

Amanatidou

Nastou

Tsitsilonis

et al. 2019

Preprint

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Blood-cell targeting Autoimmune Diseases (BLADs) are complex diseases that affect blood cell formation or prevent blood cell production. Since these clinical conditions are gathering growing attention, experimental approaches are being used to investigate the mechanisms behind their pathogenesis and to identify proteins associated with them. However, computational approaches have not been utilized extensively in the study of BLADs. This study aims to investigate the interaction network of proteins associated with BLADs (BLAD interactome) and to identify novel associations with other human proteins. The method followed in this study combines information regarding protein-protein interaction network properties and autoimmune disease terms. Proteins with high network scores and statistically significant autoimmune disease term enrichment were obtained and 14 of them were designated as candidate proteins associated with BLADs. Additionally, clustering analysis of the BLAD interactome was used and allowed the detection of 17 proteins that act as "connectors" of different BLADs. We expect our findings to further extend experimental efforts for the investigation of the pathogenesis and the relationships of BLADs.

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“…It was proposed that these MHC class I molecules do not activate cytotoxic CD8 T cells and are involved in longer survival of allografts following transfusion [8]. Moreover, very interestingly, a recent study associated an allele of a microsatellite marker in the MICA gene with susceptibility to idiopathic thrombopenic purpura [9]. In the class III region, several members of the LY6G gene cluster are expressed in platelets.…”

Section: à6mentioning

confidence: 99%

Comparative analysis in cynomolgus macaque identifies a novel human MHC locus controlling platelet blood counts independently of BAK1

Aarnink

Garchon

Okada

et al. 2013

Journal of Thrombosis and Haemostasis

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Predisposition to idiopathic thrombocytopenic purpura maps close to the major histocompatibility complex class I chain-related gene A

Cited by 17 publications

References 34 publications

Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura

Plasma microRNA profiling of pediatric patients with immune thrombocytopenic purpura

Visualization and Analysis of the Interaction Network of Proteins Associated with Blood-cell targeting Autoimmune Diseases

Comparative analysis in cynomolgus macaque identifies a novel human MHC locus controlling platelet blood counts independently of BAK1

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