Triple-synergistic MOF-nanozyme for efficient antibacterial treatment

Wang, Muxue; Zhou, Xi; Li, Yunhong; Dong, Yuanlin; Meng, Jiashen; Zhang, Shuai; Xia, Linbo; He, Zhaozhi; Ren, Lei; Chen, Zhiwei; Zhang, Xingcai

doi:10.1016/j.bioactmat.2022.01.036

Cited by 58 publications

(45 citation statements)

References 61 publications

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“…Additionally, benefitting from the abundant modification sites and stable structure, NMOF can be easily modified with a functional group for the synergetic enhancement. The folic acid ( Yang et al, 2020a ; Jiang et al, 2021 ) and hyaluronic acid ( Xu et al, 2020 ) were added to the NMOF to provide tumor targeting ability, while the gold coating was used as enzymes for combined cancer therapy ( Hu et al, 2020 ; Wang et al, 2022 ). It is highly expected that NMOF-based theranostic agents will play a more critical role in biomedical imaging and therapeutic applications ( Lismont et al, 2017 ; Banerjee et al, 2020 ; Liu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

Mao

Qin

et al. 2022

Front. Bioeng. Biotechnol.

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The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal–organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, in vitro and in vivo experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.

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Section: Introductionmentioning

confidence: 99%

Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

Mao

Qin

et al. 2022

Front. Bioeng. Biotechnol.

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“…MOFs-nanozymes with high loading capacity can be good candidate for multiple drugs delivering to realize CDT and drug (i.e. NO, Ag + , Zn 2+ , carvacrol) release for enhancing chronic wound healing [112][113][114][115]. Cascaded nanozymes that can trigger POD-, catalase-, and glucose oxidase-like catalysis have shown great potential for diabetic wound recovery due to the coupling of glucose consumption, antibacterial and anti-inflammatory activity [90,[116][117][118].…”

Section: Multifunctional Nanozyme-based Platformsmentioning

confidence: 99%

Efficient nanozyme engineering for antibacterial therapy

et al. 2022

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Antimicrobial resistance (AMR) has posed a huge threat to human health. It is urgent to explore efficient ways to suppress the spread of AMR. Antibacterial nanozymes has become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial performance. However, the inherent low catalytic activity of nanozymes limits their expansion into antibacterial applications. In this regard, a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of nanozymes. In this review, we have summarized the recent progress of advanced strategies to engineering efficient nanozymes for fighting against AMR, which can be mainly classified into catalytic activity improvement, external stimuli, bacterial affinity enhancement, and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme catalysis. Moreover, the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are highlighted. Finally, current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

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“…In recent years, porous polymers have received considerable attention and exhibited important applications in gas storage and separation, 1,2 adsorption, 3,4 catalysis, 5,6 energy storage, 7,8 and drug delivery. 9–11 Compared to conventional inorganic porous materials (such as zeolites, 12 porous carbons, 13–15 and mesoporous silica 16 ) and metal–organic frameworks (MOFs), 17–23 porous organic polymers (POPs) offer excellent stability, high specific surface areas, and ease of functionalization, making them suitable for advanced applications (Table 1). POPs have low mass as they are mainly composed of light elements (C, H, O, and N).…”

Section: Introductionmentioning

confidence: 99%