Triple-synergistic 2D material-based dual-delivery antibiotic platform

Abstract

Two-dimensional (2D) nanomaterials have raised significant interest in not only energy and environmental fields but also biomedical areas. Among these materials, one type that has many interesting properties and possesses numerous exciting applications is graphene oxide (GO)-based 2D materials. However, their poor stability in aqueous solutions and weak bioactivities limit their use in biomedical applications, especially antimicrobial fields. In this study, GO was functionalized with hydrophilic polymers and used as a vector for silver nanoparticles (Ag NPs) and sulfadiazine (SD). The stability of the material in aqueous solutions was greatly improved. The antibacterial activity of the novel hybrid antibacterial system (HAS) was enhanced by over 3 times compared to that of the system lacking SD. The antibacterial performance of the HAS was due to the triple synergy: bacterial capping, puncture, and inhibition. This study provides new insights into the design and fabrication of surface-modified GO and carbon materials and their 2D hybrid multifunctional materials for advanced applications including biomedical and especially antibacterial applications, broadening the design and application scope of carbon and 2D materials.

Sustained release of usnic acid from graphene coatings ensures long term antibiofilm protection

“…By contrast, graphene and its derivatives are chemically inert and possess excellent physicochemical properties for long-time protection, such as high thermal stability, biocompatibility, and high mechanical strength. Therefore, they could provide the optimal cargo system for sustained drug release to ensure long-term antibacterial protection of biomedical devices 29 , 30 . There are a few available studies showing the loading of antibiotics and other therapeutics to graphene derivatives, which have resulted in sustained drug release and enhancement in antimicrobial activity 31 , 32 .…”

Evaluations of biosynthesized Ag nanoparticles via Allium Sativum flower extract in biological applications

“…Silver nanoparticles are mostly used as antimicrobial agents. With the enhancement of nanotechnology, silver nanoparticles exhibited the better antimicrobial performance than usual bulk silver material (Han et al 2020). Silver was a heavy metal, but the Ag nanoparticles able to reduce the cytocompatibility of titanium materials (Li et al 2018a, b).…”

Antibacterial Activity of Polymer Nanocomposites Incorporating Graphene and Its Derivatives: A State of Art

“…A few studies have assessed the biological activity and cytotoxicity of G and GO covalently modified with PEG and its derivatives [ 59 , 60 ]. For instance, ternary hybrids of PEG-functionalized GO with Ag nanoparticles have been prepared by a simple, fast and green microwave irradiation route [ 61 ], at different irradiation times and their bactericide properties were investigated against S. aureus and E. coli bacteria as model organisms, following the disk diffusion method [ 43 ]. The initial bacterial concentration was set at 10 5 CFU/mL.…”