Triple-responsive inorganic–organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules

Timin, Alexander S.; Muslimov, Аlbert R.; Lepik, Kirill V.; Saprykina, Natalia; Sergeev, Vladislav S.; Afanasyev, Boris; Vilesov, A. D.; Sukhorukov, Gleb B.

doi:10.1039/c6tb02289h

Cited by 34 publications

(29 citation statements)

References 67 publications

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“…This is why design of new drug carriers is one of the fastest developing directions of research in the nanomedicine area. This allows, in particular, creating a controllable photosensitizer delivery system for cell applications [33][34][35]. Increasing use of nanomaterials, including nanoparticles and NCs in household, medical and industrial products requires a careful assessment of possible consequences [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Impact of Nanocapsules on Red Blood Cells Interplay Jointly Assessed by Optical Tweezers and Microscopy

et al. 2019

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In the framework of novel medical paradigm the red blood cells (RBCs) have a great potential to be used as drug delivery carriers. This approach requires an ultimate understanding of the peculiarities of mutual interaction of RBC influenced by nano-materials composed the drugs. Optical tweezers (OT) is widely used to explore mechanisms of cells’ interaction with the ability to trap non-invasively, manipulate and displace living cells with a notably high accuracy. In the current study, the mutual interaction of RBC with polymeric nano-capsules (NCs) is investigated utilizing a two-channel OT system. The obtained results suggest that, in the presence of NCs, the RBC aggregation in plasma satisfies the ‘cross-bridges’ model. Complementarily, the allocation of NCs on the RBC membrane was observed by scanning electron microscopy (SEM), while for assessment of NCs-induced morphological changes the tests with the human mesenchymal stem cells (hMSC) was performed. The combined application of OT and advanced microscopy approaches brings new insights into the conception of direct observation of cells interaction influenced by NCs for the estimation of possible cytotoxic effects.

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Section: Introductionmentioning

confidence: 99%

Impact of Nanocapsules on Red Blood Cells Interplay Jointly Assessed by Optical Tweezers and Microscopy

et al. 2019

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“…The use of organic-inorganic hybrid nanocarriers for controlled release of antitumor drugs has gained great interest, in particular to improve the selectivity and efficacy of drugs. [17][18][19] Compared with single carriers, hybrid nanocarriers built upon the success of traditional platforms with further optimizations in material, size, and structural properties could greatly improve the therapeutic potential. 20,21 The development of phospholipid (PL)-calcium carbonate hybrid nanoparticles would be one such example, as it combines the merits of nanostructured lipid carriers and calcium carbonate, both of which have been extensively evaluated in many previous studies.…”

Section: Introductionmentioning

confidence: 99%

<p>Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</p>

Wang¹,

Han²,

Liu³

et al. 2019

IJN

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Background: The application of mitoxantrone (MIT) in cancer therapy has been severely limited by its inherent drawbacks. In addition, effective cancer therapy calls for drug release systems capable of enforcing drug release within cancer cells in response to infinite stimulant with enhanced drug penetration capability. Methods: MIT-preloaded phospholipid-amorphous calcium carbonate hybrid nanoparticles (PL/ACC-MIT) that surface modified with PL shell (containing shielding polymer polyethylene glycol and targeting moiety folic acid) were prepared by a facile solvent-diffusion method. Results: It has been proven that the resulting PL/ACC-MIT nanoparticles demonstrated satisfactory stability against various aqueous environments with minimal drug leakage and exerted strong targeting capability but selective preference to the folate receptor-overexpressing cell line. In contrast, once exposed to the enzyme-abundant and acidic environments of cancer cells, the PL/ACC-MIT nanoparticles can readily decompose to facilitate quick drug release and enhanced drug penetration to yield preferable antitumor effect both in vitro and in vivo. Conclusion: In this study, MIT-preloaded water-responsive hybrid nanoparticles with increased stability, targetability, controlled drug release, and enhanced drug penetration were successfully developed, which might be a candidate for targeted and effective cancer therapy.

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“…Among multifunctional drug carriers, polyelectrolyte (PE) microcapsules have gathered significant interest during last decades . The main advantage of PE capsules is the case of modification of the surface with different kinds of functional groups, lipids, nanoparticles, etc . At present, the sol‐gel chemistry was successfully introduced into prefabricated PE microcapsules, producing hybrid capsules with dual‐ and triple‐responsive mechanisms of triggers .…”

Section: Introductionmentioning

confidence: 99%

“…The main advantage of PE capsules is the case of modification of the surface with different kinds of functional groups, lipids, nanoparticles, etc . At present, the sol‐gel chemistry was successfully introduced into prefabricated PE microcapsules, producing hybrid capsules with dual‐ and triple‐responsive mechanisms of triggers . Hydrolysis of sol‐gel precursor (usually, tetraethyl orthosilicate) leads to formation of silica nanoparticles that can easily cover the surface of PE microcapsules.…”

Section: Introductionmentioning

confidence: 99%

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Intracellular Breakable and Ultrasound-Responsive Hybrid Microsized Containers for Selective Drug Release into Cancerous Cells

Timin

Muslimov

Lepik

et al. 2017

Part. Part. Syst. Charact.

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1 of 10) 1600417 This work reports an efficient and straightforward strategy to fabricate hybrid microsized containers with reduction-sensitive and ultrasound-responsive properties. The ultrasound and reductive sensitivity are visualized using scanning electron microscopy, with the results showing structural decomposition upon ultrasound irradiation and in the presence of reducing agent. The ultrasound-responsive functionalities of hybrid carriers can be used as external trigger for rapid controlled release, while prolonged drug release can be achieved in the presence of reducing agent. To evaluate the potential for targeted drug delivery, hybrid microsized containers are loaded with the anticancer drug doxorubicin (Dox). Such hybrid capsules can undergo structural intracellular degradation after cellular uptake by human cervical cancer cell line (HeLa), resulting in Dox release into cancer cells. In contrast, there is no Dox release when hybrid capsules are incubated with human mesenchymal stem cells (MSCs) as an example of normal human cells. The cell viability results indicate that Dox-loaded capsules effectively killed HeLa cells, while they have lower cytotoxicity against MSCs as an example of healthy cells. Thus, the newly developed intracellular-and ultrasound-responsive microcarriers obtained via sol-gel method and layer-by-layer technique provide a high therapeutic efficacy for cancer, while minimizing adverse side effect.

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Triple-responsive inorganic–organic hybrid microcapsules as a biocompatible smart platform for the delivery of small molecules

Abstract: We designed novel hybrid inorganic/organic capsules with unique physicochemical features enabling multimodal triggering.

Cited by 34 publications

References 67 publications

Impact of Nanocapsules on Red Blood Cells Interplay Jointly Assessed by Optical Tweezers and Microscopy

Impact of Nanocapsules on Red Blood Cells Interplay Jointly Assessed by Optical Tweezers and Microscopy

<p>Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</p>

Intracellular Breakable and Ultrasound-Responsive Hybrid Microsized Containers for Selective Drug Release into Cancerous Cells

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