Triple-Responsive Block Copolymer Micelles with Synergistic pH and Temperature Response

Falireas, Panagiotis G.; Vamvakaki, Maria

doi:10.1021/acs.macromol.8b00810

Cited by 39 publications

(26 citation statements)

References 61 publications

(94 reference statements)

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“…[1d,6] Photoresponsive chromophores including azobenzene (Azo), spiropyran, and donor–acceptor Stenhouse adducts have been introduced to amphiphilic copolymers. [6a,c,7] The chromophores photoisomerization change the polarity and hydrophilicity of the segments, further switching scale and morphology of the self‐assemblies. For example, Barner–Kowollik's group fabricated photoresponsive Azo‐contained miktoarm star polymers.…”

Section: Methodssupporting

confidence: 71%

Light‐Switching Azo‐Copolymers Self‐Assembly in Multi‐Stationary States

Dong

Sun

Wang

et al. 2019

Macromol. Rapid Commun.

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In the present research, novel tri‐block‐copolymers bearing polyethylene glycol (PEG), azobenzene (Azo), and tetra‐ortho‐methoxy‐substituted Azo (mAzo) segments are synthesized and explored. Light‐controlled PEG‐PmAzo‐PAzo self‐assemblies switching between multi‐stationary states is realized. Under controlling of UV, blue, green, and red light, PEG‐PmAzo‐PAzo isomerize between 4 photostationary states. The enrichment of cis isomers of Azo and mAzo induces the self‐assembly of PEG‐PmAzo‐PAzo in toluene. The morphologies and scale of the self‐assemblies can be switched between four stationary states, which are investigated by dynamic light scattering, scanning electron microscopy, and transmission electron microscopy.

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Section: Methodssupporting

confidence: 71%

Light‐Switching Azo‐Copolymers Self‐Assembly in Multi‐Stationary States

Dong

Sun

Wang

et al. 2019

Macromol. Rapid Commun.

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“…Moreover, the protonation/deprotonation of SPs controlled by pH was also investigated on controlling nanopore flux to cation or anion. [ 97 ] Balme and co‐workers reported nanopores coated with SPs terminated PEG. The conductance of KCl through the nanopores could be controlled by light, due to the reversible closed ‐ open isomerization of SPs.…”

Section: Other Sensitive Behaviors and Applicationmentioning

confidence: 99%

Learning from Spiropyrans: How to Make Further Developments of Donor‐Acceptor Stenhouse Adducts

et al. 2021

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Photoresponsive| Donor-acceptor Stenhouse adducts| Spiropyrans| Applications| Isomerization Donor-acceptor Stenhouse adducts (DASAs) as a species of novel photochromic molecules, have been developing rapidly and attracting broad researchers' sights since 2014. DASAs show visible/near-infrared (NIR) light induced linear-to-cyclic isomerization and heat induced cyclic-to-linear isomerization, therefore they are attractive in photoresponsive hydrogels, drug delivery, cell culturing and tissue engineering. As a series of well-known photoresponsive molecules, spiropyrans (SPs) show similar molecular properties and comparable photoswitching with DASAs. UV light triggers closed-to-open (also known as spirocyclic (SC)-to-merocyanine (MC)) isomerization of SPs, while the reversed open-to-closed isomerization occurs under visible light or heat. Light irradiation switches the molecular color, scale, geometry, and polarity of SPs and DASAs reversibly. Since the researches on DASAs are still in the infancy, the chemical structures, isomerization mechanisms and potential applications need to be further investigated and explored. The well-studied SPs have important reference values to the comprehensive developments of DASAs. In the present review, we summarized, compared and discussed SPs and DASAs with regards to their molecular structures, synthesis, photoswitching and applications. We also make our perspective on the developments of DASA in future. Yongli Duan (lest) is a Ph.D. student at University of Electronic Science and Technology of China. She is focusing on the synthesis, photoresponsive mechanisms and properties of DASAs under supervision of Prof. Dr. Dongsheng Wang.

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“…[35][36][37] There are many examples of pH-responsive polymers based on either weak polyacids such as poly(methacrylic acid) (PMAA) 38,39 and poly(acrylic acid) 40 or weak polybases such as poly(2-vinylpyridine) (P2VP) 41 or poly(2-(dimethylamino)ethyl methacrylate) (PDMA). 42,43 The former class is particularly relevant to the present study. Ionization of carboxylic acid groups confers polyelectrolytic character which causes PMAA to swell at high pH; this results in a conformational switch from compact (hyper-coiled) to highly extended chains.…”

Section: Introductionmentioning

confidence: 99%