Aqueous solution behavior of stimulus-responsive poly(methacrylic acid)-poly(2-hydroxypropyl methacrylate) diblock copolymer nanoparticles

Abstract

RAFT aqueous dispersion polymerization is used to prepare poly(methacrylic acid)-poly(2-hydroxypropyl methacrylate) diblock copolymer nanoparticles, which exhibit stimulus-responsive behaviour on adjusting the solution temperature and/or solution pH.

Self-Assembling Peptide—Polymer Nano-Objects via Polymerization-Induced Self-Assembly

“…These spherical clusters were reminiscent of Mimosa. The hydrophilicity increase of the PHPMA core-forming block at low temperature ,− likely triggered the reorganization of the P­(GMA 65 - stat -(MAm-GFF) 7 )- b -PHPMA 28 self-assembled morphologies, suggesting that the self-assembly process of the GFF-containing block copolymer is not only driven by the specific peptide interaction part but also by the delicate hydrophilic/hydrophobic balance for the whole system.…”

Thermoresponsive properties of poly(acrylamide-co-acrylonitrile)-based diblock copolymers synthesized (by PISA) in water

“…While several previous reports have already mentioned temperature-induced morphology changes in aqueous media, they generally produced higher-order morphologies upon heating. [76][77][78][79] Therefore, to the best of our knowledge, the PDMAc-b-P(AAmco-AN) diblock copolymers is the first system that presents, at fixed composition in aqueous media, a worm-to-sphere order-order transition upon temperature increase in water. We believe that the developed synthesis of core-shell structures exhibiting a UCST core by PISA will be a promising strategy to design a great number of intelligent nanomaterials for various applications.…”

“…Temperature-induced morphological transitions have already been observed in the literature for PISA-derived particles, but never for UCST-like polymers. [76][77][78][79] Such morphological transitions have been explained by an interfacial hydration of the core block inducing a subtle decrease in the packing parameter. 79,80 Generally, in water the observed transition is a LCST-like one, where the core-chain become less hydrated above heating, leading to the formation of higher-order morphologies.…”

RAFT-mediated polymerization-induced self-assembly (RAFT-PISA): current status and future directions

“…This was because the multiple acid groups on the PMAA stabilizer were ionized and resulting in a decrease in the mean aggregation number. 271 The sterically stabilized nanoparticles at pH 10 were also thermo-responsive due to the presence of PHPMA block.…”