Triple Antiretroviral Therapy Effectively Eliminates HIV Transmission from Mother to Child

Abstract

Background: HIV transmission can be reduced by practicing appropriate prevention. Every centers have their own standardized regimens for antiretroviral therapy. The study aimed to determine HIV transmission after practicing standardized triple antiretroviral therapy adapted in Haji Adam Malik Hospital.Study Design: This is an cohort-analytic study conducted in Haji Adam Malik hospital. Medical records of HIVpositive mothers who did the antenatal care and delivered at Haji Adam Malik Hospital in 2009-2014 were collected. The standardized antiretroviral therapy adapted in Haji Adam Malik Hospital were applied. Follow up was done to all of the born children in order to determine HIV tranmission rate. Diagnosis of HIV in children under the age of 18 monthswere done by PCR (Polymerase Chain Reaction). If the child has been aged ≥18 months, the method of diagnosis is Rapid Test.Results: Of the 60 infants examined, 11 infantsaged <18 months enrolled in PCR tests, while 49 otherschildren were tested using rapid test. However, no virus were detected in all infants. Conclusion:The triple antiretroviral effectively prevent the HIV transmission from mother to children.

Ordinal Regression Modeling of Mother to Infant HIV Transmission in Nyeri County, Kenya

“…Manji et al (2016) examined how exclusive breastfeeding reduces mother to child HIV transmission using the Cox Proportional Hazards Models [5]. Lumbanraja et al (2016) conducted a study in H. Adam Malik Hospital on effect of Triple antiretroviral therapy on HIV transmission using the Polymerase Chain Reaction methodology [7].…”

“…Most of HIV exposed infants become infected during breastfeeding period and this transmission rate can be reduced by giving antiretroviral (ARV) drugs to the mother and the newly born infant during the breast feeding period. Infant feeding in the first six months and the use of ARV drugs has been considered as an important strategy in curbing HIV-1 and other infections from being transmitted from the mother to the newly born infants for all HIV exposed infants [7].…”

“…It is assumed that there is a negative association between breast milk HIV shedding and use of combined oral contraceptives and thus the need for further studies on the same [13]. Further proposals are on the use of replacement feeding methods by lactating mothers so as to reduce the potential risk of HIV transmission [7,9,11].…”