Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: Implication of chemoprevention of breast cancer

Tripathi, Shailja; Kushwah, Varun; Thanki, Kaushik

doi:10.1016/j.nano.2016.03.003

Cited by 44 publications

(17 citation statements)

References 36 publications

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“…Different mixtures such as quercetin-RSV-genistein, curcumin-EGCG, and curcumin-RSV have been shown to be effective in reducing tumour growth and modulating apoptosis and angiogenesis signalling pathways [81][82][83]. In line with this, emerging strategies using self-nanoemulsifying drug delivery systems (SNEDDS) showed higher plasma concentrations of mixtures of phenolics related to more efficient anti-breast cancer effects [84].…”

Section: Evidence Of the Chemopreventive Potential Of Phenolic Compoumentioning

confidence: 89%

“…Inhibition of 5-LOX (and its product LTB4) and COX-2 via NF-κB inhibition by resveratrol consumption has been reported to be involved in BC prevention in DMBA-treated rats [89,99]. Naringenin and soy protein modulated the expression of genes involved in regulating the inflammatory response and cytokine signalling, including MCP-1 and IL-6 [90,100], while wogonoside and the mix resveratrol-quercentin-genistein reduced the level of IL-6, TNF-α, and the TNF receptor-associated factors TRAF2 and TRAF4 [84,101]. Several studies have highlighted the role of the immune system regarding the protective effects of phenolic compounds against BC.…”

Section: Evidence Of the Chemopreventive Potential Of Phenolic Compoumentioning

confidence: 99%

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Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

Ávila‐Gálvez

Giménez‐Bastida

Espı́n

et al. 2020

IJMS

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Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related death in adult women worldwide. Over 85% of BC cases are non-hereditary, caused by modifiable extrinsic factors related to lifestyle, including dietary habits, which play a crucial role in cancer prevention. Although many epidemiological and observational studies have inversely correlated the fruit and vegetable consumption with the BC incidence, the involvement of their phenolic content in this correlation remains contradictory. During decades, wrong approaches that did not consider the bioavailability, metabolism, and breast tissue distribution of dietary phenolics persist behind the large currently existing gap between preclinical and clinical research. In the present review, we provide comprehensive preclinical and clinical evidence according to physiologically relevant in vitro and in vivo studies. Some dietary phenolics such as resveratrol (RSV), quercetin, isoflavones, epigallocatechin gallate (EGCG), lignans, and curcumin are gaining attention for their chemopreventive properties in preclinical research. However, the clinical evidence of dietary phenolics as BC chemopreventive compounds is still inconclusive. Therefore, the only way to validate promising preclinical results is to conduct clinical trials in BC patients. In this regard, future perspectives on dietary phenolics and BC research are also critically discussed.

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Section: Evidence Of the Chemopreventive Potential Of Phenolic Compoumentioning

confidence: 89%

Section: Evidence Of the Chemopreventive Potential Of Phenolic Compoumentioning

confidence: 99%

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

Ávila‐Gálvez

Giménez‐Bastida

Espı́n

et al. 2020

IJMS

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show abstract

“…Various pharmaceutical formulations such as polymeric micro-/nano-particles (Tang et al ., 2011), β-cyclodextrin complexes (Lee et al ., 2007), micellar systems (Kwon et al ., 2007), and self-nanoemulsifying drug delivery systems (Tripathi et al ., 2016) have been explored to improve dissolution behavior and oral bioavailability of genistein. Among them, SLPS have been suggested as a promising drug delivery system for enhancing the oral bioavailability of genistein because they can be fabricated to release the incorporated drugs in a controlled manner by varying the composition of the solid matrix, which is a critical determinant of oral bioavailability (Harde et al ., 2011).…”

Section: Discussionmentioning

confidence: 99%

Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes

Kim

Barua

Kim

et al. 2017

Biomolecules & Therapeutics

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In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as particle composition and drug loading efficiency and amount were similarly controlled to mainly evaluate the effect of different particle sizes of the solid lipid particulate systems on drug dissolution behavior and oral bioavailability. The results showed that genistein-loaded solid lipid microparticles and nanoparticles exhibited a considerably increased drug dissolution rate compared to that of genistein bulk powder and suspension. The microparticles gradually released genistein as a function of time while the nanoparticles exhibited a biphasic drug release pattern, showing an initial burst drug release, followed by a sustained release. The oral bioavailability of genistein loaded in solid lipid microparticles and nanoparticles in rats was also significantly enhanced compared to that in bulk powders and the suspension. However, the bioavailability from the microparticles increased more than that from the nanoparticles mainly because the rapid drug dissolution rate and rapid absorption of genistein because of the large surface area of the genistein-solid lipid nanoparticles cleared the drug to a greater extent than the genistein-solid lipid microparticles did. Therefore, the findings of this study suggest that controlling the particle size of solid-lipid particulate systems at a micro-scale would be a promising strategy to increase the oral bioavailability of genistein.

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“…However, the clinical drugs that lower oral bioavailability become such a problem. 71 Nanocarriers, on account of their higher ratio of surface area to volume, show improved pharmacokinetics and biodistribution of therapeutics, and because of their preferential accumulation at the target site, minimize toxicity. They can be used to deliver the drug to the central nervous system owing to their smaller size and higher permeability.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Characterizations and Antioxidant Property of Copaiba Oil Loaded into SNEDDS Systems

Emerenciano¹,

Baracho²,

Medeiros³

et al. 2019

J. Braz. Chem. Soc.

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Self-nanoemulsion drug delivery systems (SNEDDS) represent a potential carrier to improve solubility and bioavailability of health care products. In this sense, copaiba oil (CO) loaded on cosurfactant-free SNEDDS formulations (CO-SNEDDS) were obtained by using phase diagram performed on different concentrations of constituents (oil, surfactant and water). The CO-SNEDDS are composed of 1% (m/m) of oil phase, 20% (m/m) of Tween 80, and 79% (m/m) of doubledistilled water. Specifically, varying the oil phase to 1% of CO affords the so-called SNECO system, and 1% of CO blended on a 1:1 ratio with coconut oil or sunflower oil affords, respectively, the SNECO-COO and SNECO-SO derivative systems. CO sample was authenticated by gas chromatography equipped with a flame ionization detector and the CO-SNEDDS samples were characterized by droplet particle size, zeta potential, polarized light microscopy, pH, conductivity, refractive index, rheological and surface tension analyses. According to the antioxidant tests reducing power and hydroxyl inhibiting formation, the findings displayed 47.89 and 72.92% for SNECO, 46.48 and 84.11% for SNECO-COO, and 52.46 and 74.48% for SNECO-SO, respectively. From now on CO-SNEDDS based systems become available as promising targets for novel medicinal investigations and also could be undertaken for the oral administration of poorly water soluble drugs.

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Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: Implication of chemoprevention of breast cancer

Cited by 44 publications

References 36 publications

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

Dietary Phenolics against Breast Cancer. A Critical Evidence-Based Review and Future Perspectives

Absorption Study of Genistein Using Solid Lipid Microparticles and Nanoparticles: Control of Oral Bioavailability by Particle Sizes

Physicochemical Characterizations and Antioxidant Property of Copaiba Oil Loaded into SNEDDS Systems

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