Physicochemical Characterizations and Antioxidant Property of Copaiba Oil Loaded into SNEDDS Systems

Abstract

Self-nanoemulsion drug delivery systems (SNEDDS) represent a potential carrier to improve solubility and bioavailability of health care products. In this sense, copaiba oil (CO) loaded on cosurfactant-free SNEDDS formulations (CO-SNEDDS) were obtained by using phase diagram performed on different concentrations of constituents (oil, surfactant and water). The CO-SNEDDS are composed of 1% (m/m) of oil phase, 20% (m/m) of Tween 80, and 79% (m/m) of doubledistilled water. Specifically, varying the oil phase to 1% of CO affords the so-called SNECO system, and 1% of CO blended on a 1:1 ratio with coconut oil or sunflower oil affords, respectively, the SNECO-COO and SNECO-SO derivative systems. CO sample was authenticated by gas chromatography equipped with a flame ionization detector and the CO-SNEDDS samples were characterized by droplet particle size, zeta potential, polarized light microscopy, pH, conductivity, refractive index, rheological and surface tension analyses. According to the antioxidant tests reducing power and hydroxyl inhibiting formation, the findings displayed 47.89 and 72.92% for SNECO, 46.48 and 84.11% for SNECO-COO, and 52.46 and 74.48% for SNECO-SO, respectively. From now on CO-SNEDDS based systems become available as promising targets for novel medicinal investigations and also could be undertaken for the oral administration of poorly water soluble drugs.

Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin

“…Some parameters such as viscosity, refractive index, conductivity and pH of selected formulations are presented in Table 3. Low viscosity of SNEDD formulations are desirable as it makes pourable and facilitate in administration [80]. The refractive indices of formulation were very close to that observed with distilled water indicating transparency and optical clarity of the SNEDD dispersions [81].…”

Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19

“…The values of ZP decreased upon mixing phosphatidylcholine with the surfactants in the following descending order: CrEl (F3), T80 (F2), PF127 (F4), labrasol ® (F1) as the values were -18.8 ± 0.2, -18.1 ± 1.8, -15.4 ± 0.4 and -6.8 ± 0.5, respectively. The decrease of ZP upon incorporation of nonionic surfactant suggested the existence of attractive forces due to the electrostatic interactions and hydrogen bond formation ( 50 ) between the oxygen atoms of phosphate groups of phosphatidylcholine and hydrogen atoms of the surfactants molecules. It is noticeable that the addition of labrasol ® exhibited significant decrease in ZP (from -22 to -6.8).…”

Formulation And Antioxidant Property Of Bitter Melon Seeds Oil Loaded Into SNEDDS Systems As A Nutraceutical

“…The method of antioxidant oil analysis was adopted from Emerenciano et al, 2019 andRafi et al, 2020. The percentage of reducing power calculate using equation 1.…”