Triple Antimicrobial Therapy and Acid Suppression in Dogs with Chronic Vomiting and Gastric Helicobacter spp

Abstract

Eradication rates of Helicobacter spp with both treatments were not significantly different. Eradication rates at 6 months were modest, and more effective treatments should be developed. Acid suppression is not a necessary component of treatment protocols for dogs. Eradication of gastric Helicobacter spp was associated with improvement in gastritis scores. Dramatic reduction of the vomiting frequency occurred with both treatment protocols. Gastric Helicobacter spp may cause or contribute to chronic vomiting and gastritis in some dogs.

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

“…Gastritis is a common cause of chronic vomiting that may be associated with IBD, dietary indiscretion, foreign body and toxin ingestion, nonsteroidal anti‐inflammatory drug usage, metabolic disease (eg, renal and hepatobiliary disease), and gastric (viral, bacterial, protozoal, fungal, and helminth) infection 82 . Although the mucosal inflammation of IBD principally involves the small and large intestines, chronic gastritis may be observed as a component of IBD in these same patients 82,83 …”

Studies of distribution and recurrence of Helicobacter spp. gastric mucosa of dogs after triple therapy

“…The fact that the used therapy in this experiment was not followed by adverse effects, was observed using amoxicillin, metronidazole and colloidal bismuth subcitrate 25,26 .…”

“…And the lansoprazole seems to have pharmacological power and action time similar to omeprazole, and also present minimal side effects in North America dogs 25,26 .…”

Value of the ¹³C-Urea Breath Test for Detection of Gastric <i>Helicobacter</i> spp. Infection in Dogs Undergoing Endoscopic Examination

“…Some authors have denied the pathogenicity of Helicobacter spp. in dogs [10,33,34], but other reports have supported the relationship between Helicobacter infection and gastric disease [16,[29][30][31][32]. Therefore, treating Helicobacter infection in dogs is controversial, and whether treatment is needed in all cases or not is unclear at this point.…”

“…In humans, Helicobacter pylori is known to be the major agent of chronic diffuse superficial gastritis, plays a causative role in peptic ulcers and is considered a co-factor in the development of gastric malignancies [15,28,36] [4,12], but insufficient epidemiological data are available to estimate the prevalence in Japan. In addition, although H. felis, H. bizzozeronii, H. salomonis and "Candidatus Helicobacter heilmannii" are also found in the human stomach [3,38,40] and are suggested to be associated with gastric diseases in humans [18,19,37,42], their pathogenic significance in dogs is controversial [10,16,[29][30][31][32][33][34].Diagnostic tests for gastric Helicobacter spp. in dogs and cats include polymerase chain reaction (PCR) testing, rapid urease test (RUT), histology and cytology; all of these require anesthesia and gastric biopsy [9,21,22].…”