Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Muthusamy, Senthilkumar; Shanmugam, Kirubanandan; Sripriya, R.; Sehgal, Praveen Kumar

doi:10.1016/j.jss.2008.07.006

Cited by 51 publications

(33 citation statements)

References 27 publications

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“…Terminalia chebula, Phyllanthus emblica, and Terminalia belerica. It has been reported that various applications of triphala in medical field used as laxative, digestive stimulation, anti inflammatory, antioxidant activity, lower cholesterol, reduces tumor size and improves liver function (Kumar et al, 2010;Sandhya et al, 2006). It also inhibits the growth of Gram-positive and Gramnegative bacteria (Biradar et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of Probiotics and Phytoextracts on Growth and Immunomodulating Performances of Broiler Chickens

Zuhra¹,

Paul²,

Riad³

et al. 2018

Bangl. J. Vet. Med.

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An investigation was carried out to find out the effects of probiotics and phytoextracts (Korolla-bitter melon, Triphalatraditional three herbal components and Safi-commercial polyherbal products) on growth, hemato-biochemical (TEC, TLC, ESR, Hb concentration, PCV, ALT, AST, Cholesterol, Tryglyceride, HDL and LDL) and immunomodulating performance of broiler chickens. The study was performed from February to April, 2017. A total of 150, seven -days-old broiler chicks were divided into five (05) groups using 30 chicks in each group. The group A was designated as control group (without probiotics and phytoextracts), with probiotics (Exolution ® ) Group B, with phytoextract (Korolla-bitter melon) Group C, Triphalatraditional three herbal components Group D and Safi Group E. Chicks were reared for 35 days and body weight were measured on weekly basis. Broilers were sacrificed at the end of 35 days and blood samples were taken for hematological analysis. Serum samples were also taken for biochemical tests. Broilers in all treatment groups were necropsied at the end of the experiment to observe and determine the weight of the gross lymphoid organs (spleen, thymus and bursa of Fabricious). Both body weight gain, hematological parameters like TEC, TLC, Hb concentration and PCV values and size of lymphoid organs (spleen, thymus, Bursa of Fabricious) were increased in birds supplemented with probiotics and phytoextracts as compared with control group. In biochemical parameters, AST and ALT values were decreased significantly (p<0.05 and p<0.01) in groups B, C, D, E from that of the control group. The findings of the experiment would help us to assess the use of proper feed additives as healthy growth promoter and immunomodulator in broiler chickens.

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Section: Introductionmentioning

confidence: 99%

Effects of Probiotics and Phytoextracts on Growth and Immunomodulating Performances of Broiler Chickens

Zuhra¹,

Paul²,

Riad³

et al. 2018

Bangl. J. Vet. Med.

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“…There have been reported several new techniques for topical wound healing of infected ulcers as the use of triphala incorporated collagen [30] or application of electric field to a flowing medium which forms microscale and nanoscale structures to compose functional wound healing materials [31]. In more advanced applications, such as several burns, commercial tissue engineered skin substitutes based on acelluar (Alloderm TM ) or cell containing matrices (Dermagraft TM , Apligraft TM , Epicel TM , TransCyte TM , etc.)…”

Section: Introductionmentioning

confidence: 99%

Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing

Dubský

Kubinová

Širc

et al. 2012

J Mater Sci: Mater Med

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Electrospun gelatin and poly-ε-caprolactone (PCL) nanofibers were prepared using needleless technology and their biocompatibility and therapeutic efficacy have been characterized in vitro in cell cultures and in an experimental model of a skin wound. Human dermal fibroblasts, keratinocytes and mesenchymal stem cells seeded on the nanofibers revealed that both nanofibers promoted cell adhesion and proliferation. The effect of nanofibers on wound healing was examined using a full thickness wound model in rats and compared with a standard control treatment with gauze. Significantly faster wound closure was found with gelatin after 5 and 10 days of treatment, but no enhancement with PCL nanofibers was observed. Histological analysis revealed enhanced epithelialisation, increased depth of granulation tissue and increased density of myofibroblasts in the wound area with gelatin nanofibers. The results show that gelatin nanofibers produced by needleless technology accelerate wound healing and may be suitable as a scaffold for cell transfer and skin regeneration.

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“…Their important properties are a specified mechanical strength, which provides the possibility to use them as a base for tissue-engineered constructs, and ability to biodegradation in the body. Such equivalents on the sponge matrix are effectively employed for skin regeneration in the experiments on animals and in treating skin wounds in patients [58][59][60].…”

Section: Biopolymer Matricesmentioning

confidence: 99%

Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review)

Meleshina¹,

Bystrova²,

Rogovaya³

et al. 2017

Sovrem Tehnol Med

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Development and introduction of new biotechnological analogues (equivalents) of tissues and organs into clinical practice, such as human skin equivalents (SE), designed for temporal or permanent replacement of damaged or destroyed tissue, remains an urgent problem of regenerative medicine. Currently, full-thickness SE as well as separate skin layers, which include living cells of different types, are being created and investigated. Since the ideal skin substitutes have not been created, the efforts of researchers in many countries are aimed at solving this problem.In our review, we present a comparative analysis of existing SE, both commercial and those being at the stage of preclinical study, analyze their structure and feasibility of application for solving experimental and clinical tasks. Characteristics of the three main variants of SE have also been considered. Examples of stem cell application for creation of skin equivalents have been given. The main advantages of using stem cells as a cell component of skin equivalents have been described.

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Triphala Incorporated Collagen Sponge—A Smart Biomaterial for Infected Dermal Wound Healing

Cited by 51 publications

References 27 publications

Effects of Probiotics and Phytoextracts on Growth and Immunomodulating Performances of Broiler Chickens

Effects of Probiotics and Phytoextracts on Growth and Immunomodulating Performances of Broiler Chickens

Nanofibers prepared by needleless electrospinning technology as scaffolds for wound healing

Skin Tissue-Engineering Constructs and Stem Cells Application for the Skin Equivalents Creation (Review)

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