“…Once plasma exudate and hemorrhagic spots were observed in the thorax and abdomen of the mice, indicating successful establishment of the animal model, euthanasia was performed to collect vascular tissue from the hepatic aorta. Some tissues were stored at -80 °C for subsequent experiments while others were processed to appropriate sizes before being placed in 4 % paraformaldehyde fixative away from light for future use as previously described [ 40 ]. All animal procedures conducted in this study received approval from the Animal Ethics Committee of Northeastern Agricultural University.…”