The mechanism of selenium regulating the permeability of vascular endothelial cells through selenoprotein O

Wu, Jiawei; Zhang, Yanhe; Liu, Tianjing; Yang, Jie; Sun, Xiaoran; Gao, Xue-jiao

doi:10.1016/j.redox.2024.103063

Cited by 3 publications

(1 citation statement)

References 67 publications

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“…7 Oxidative stress (OS) is an abnormal metabolic state caused by an imbalance between the production and removal of reactive oxygen species (ROS). 8 Reactive oxygen species (ROS) at low levels are necessary for the maintenance of normal physiological functioning of organisms; however, high levels of ROS can lead to oxidative stress and cause severe damage to organisms. 9 It has recently been reported that TBBPA-induced oxidative stress has an effect on autophagy.…”

Section: Introductionmentioning

confidence: 99%

Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice

Lv,

Wang,

Geng

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice

Lv,

Wang,

Geng

et al. 2024

Food Funct.

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Hyaluronic acid-based injectable formulation developed to mitigate metastasis and radiation-induced skin fibrosis in breast cancer treatment

Wang,

Shueng,

et al. 2024

Carbohydrate Polymers

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High-fat diet disrupts the gut microbiome, leading to inflammation, damage to tight junctions, and apoptosis and necrosis in Nyctereutes procyonoides intestines

Wei,

Xu,

Geng

et al. 2024

Microbiol Spectr

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Given the burgeoning Nyctereutes procyonoides breeding industry and its growing scale, it is imperative to investigate the impact of high-fat diets on the health of these animals. This study involved 30 male Nyctereutes procyonoides of comparable weights (3 kg ±0.5), randomly assigned to either a control group or a high-fat diet group ( n = 15 each). The latter group was fed a mixture of lard and basal diet in a 2:5 ratio, establishing a high-fat diet model in Nyctereutes procyonoides. This diet induced diarrhea and histopathological changes in the Nyctereutes procyonoides. Analysis of the small intestine contents using 16S rRNA sequencing revealed a high-fat diet-induced disruption in the gut microbiota. Specifically, Escherichia-Shigella emerged as the biomarker in the high-fat diet group ( P = 0.049), while Vagococcus was prevalent in the control group ( P = 0.049), indicating a significant increase in harmful bacteria in the high-fat diet group. Furthermore, this disrupted gut flora correlated with inflammation and oxidative stress, as evidenced by marked increases in TNF-α ( P < 0.01), IL-1β ( P < 0.05), and IL-6 ( P < 0.05) levels, measured via q-PCR, Western blot, and oxidative stress assays. In addition, q-PCR analysis revealed significant upregulation of apoptosis and necrosis markers, including Bax, Caspase3, Caspase9, Caspase12, RIPK3, and RIPK1 ( P < 0.01 to P < 0.001), and a concurrent downregulation of the anti-apoptotic gene Bcl-2 ( P < 0.01) in the high-fat diet group, consistent with protein expression trends. These findings suggest that a high-fat diet alters the gut microbiome toward a more harmful bacterial composition, escalating inflammatory responses and intestinal tissue permeability, culminating in intestinal cell apoptosis and necrosis. IMPORTANCE This study examines the impact of high-fat diets on Nyctereutes procyonoides. Our research established a Nyctereutes procyonoides model on a high-fat diet, revealing significant health impacts, such as diarrhea, histological anomalies, and alterations in the gut microbiota. These findings emphasize the importance of preventing health issues and promoting sustainable industry growth. They highlight the significant impact of diet on gut microbiota and overall animal health.

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The mechanism of selenium regulating the permeability of vascular endothelial cells through selenoprotein O

Cited by 3 publications

References 67 publications

Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice

Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice

Hyaluronic acid-based injectable formulation developed to mitigate metastasis and radiation-induced skin fibrosis in breast cancer treatment

High-fat diet disrupts the gut microbiome, leading to inflammation, damage to tight junctions, and apoptosis and necrosis in Nyctereutes procyonoides intestines

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