“…TMP-SMX inhibits folate production in bacteria by blocking bacterial dihydrofolic acid reductase, which causes reduced production of purines and subsequently DNA [3]. Earlier, rashes and gastrointestinal distress were believed to be the most frequent side effects of the drug until a reported case of hyperkalemia [4]. Furthermore, researchers have demonstrated the hepatotoxic, nephrotoxic, and genotoxic effects of the antibiotic [5][6][7].…”