Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole

Otuechere, Chiagoziem A.; Madarikan, Gbemisola; Tinuala, Simisola; Bankole, Olubukola; Osho, A.

doi:10.1515/jbcpp-2013-0059

Cited by 22 publications

(11 citation statements)

References 19 publications

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“…Virgin coconut oil supplementation prevents lipid peroxidation in the cardiac tissue of rats fed heated palm oil (Subermaniam et al, 2014). Recent experimental studies have indicated the hepatoprotective potential of VCO supplementation in animal models Otuechere et al, 2013). In fact, a recent study by Kamisah et al (2015) demonstrated the VCO cardioprotective effect in heated palm oil diet-induced hypertensive rats.…”

Section: Discussionmentioning

confidence: 99%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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Background. The literature reports that the health benefits of vegetable oil can be deteriorated by repeated heating, which leads to lipid oxidation and the formation of free radicals. Virgin coconut oil (VCO) is emerging as a functional food oil and its health benefits are attributed to its potent polyphenolic compounds. We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO). Material and methods. Rats were divided into four groups (n = 5). The control group rats were fed with a normal diet; group 2 rats were fed a 10% VCO supplemented diet; group 3 administered 10 ml HPO/kg b.w. orally; group 4 were fed 10% VCO + 10 ml HPO/kg for 28 days. Subsequently, serum markers of liver damage (ALT, AST, ALP and albumin), kidney damage (urea, creatinine and uric acid), lipid profile and lipid ratios as cardiovascular risk indices were evaluated. Results. HPO induced a significant increase in serum markers of liver and kidney damage as well as concomitant lipid abnormalities and a marked reduction in serum HDL-C. The lipid ratios evaluated for atherogenic and coronary risk indices in rats administered HPO only were remarkably higher than control. It was observed that VCO supplementation attenuated the biochemical alterations, including the indices of cardiovascular risks. Conclusion. VCO supplementation demonstrates beneficial health effects against HPO-induced biochemical alterations in rats. VCO may serve to modulate the adverse effects associated with consumption of repeatedly heated palm kernel oil.

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Section: Discussionmentioning

confidence: 99%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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“…VCO increases the metabolism and therefore support weight management (Liau, Lee, Chen, & Rasool, 2011). Protective effect of VCO against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole (TMP-SMX), was studied by Otuechere, Madarikan, Simisola, Bankole, and Osho (2014). The active components of VCO had protective effects against the toxic effects induced by TMP-SMX administration, mainly in the liver of rats.…”

Section: Uses Of Vcomentioning

confidence: 99%

Coconut Milk and Coconut Oil: Their Manufacture Associated with Protein Functionality

Patil

Benjakul

2018

Journal of Food Science

139

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Coconut palm (Cocos nucifera L.) is an economic plant cultivated in tropical countries, mainly in the Asian region. Coconut fruit generally consists of 51.7% kernel, 9.8% water, and 38.5% shell. Coconut milk is commonly manufactured from grated coconut meat (kernel). Basically, coconut milk is an oil-in-water emulsion, stabilized by some proteins existing in the aqueous phase. Maximization of protein functionality as an emulsifier can enhance the coconut milk stability. In addition, some stabilizers have been added to ensure the coconut milk stability. However, destabilization of emulsion in coconut milk brings about the collapse of the emulsion, from which virgin coconut oil (VCO) can be obtained. Yield, characteristics, and properties of VCO are governed by the processes used for destabilizing coconut milk. VCO is considered to be a functional oil and is rich in medium chain fatty acids with health advantages.

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“…Likewise g-GT activity was not adversely affected in all treatment groups, so this precluded the hepatobiliary system as the source of the elevated ALP. This observed increase in ALP and AST could be more of physiological than pathological as a result of the high fatty acid content of the FHA [46] . FTIR spectroscopy showed that FHA based on C. esculentus seed oil was successfully prepared.…”

Section: Discussionmentioning

confidence: 86%

Evaluation of the safety profile and antioxidant activity of fatty hydroxamic acid from underutilized seed oil of Cyperus esculentus

Adewuyi

Otuechere

Oteglolade

et al. 2015

Journal of Acute Disease

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A B S T R A C TObjective: To evaluate the safety profile and antioxidant activity of fatty hydroxamic acid (FHA) from the seed oil of Cyperus esculentus (C. esculentus). Methods: FHA was synthesized from the seed oil of C. esculentus via a two-step reaction system. The FHA was later subjected to antioxidant activity test using 2, 2-diphenyl-1-picyrl hydrazyl assay. Additionally, adult male Wistar rats were randomly assigned to four groups of five rats each and were orally administered with FHA at 0, 5, 15 and 50 mg/kg for seven days. Clinical observations and serum biochemical parameters were assessed to monitor treatment-related adverse effects in the rats. Results: Fourier transform infrared spectra showed that FHA was synthesised from the seed oil of C. esculentus. The antioxidant property of FHA increased as the concentration reduced below 0.05 mg/mL. Result of oral administration of FHA revealed no adverse effect levels at the dose of 5 mg/kg/day. However, the adverse effects seen in rats receiving 15 mg/kg/day (the least observed adverse effect level) were significant increase in alkaline phosphatase activity, triglycerides, and creatinine levels. Moderate hyperalbuminemia and hypoalbuminemia resulted in an increased albumin/globulin ratio. These effects might be the result of a physiological response to exposure to a very high level of FHA which is not part of the normal diet, and are most likely not toxicologically relevant. Conclusions: C. esculentus has been presented as a potential source of feed stock for the synthesis of a relatively cheap and non toxic FHA which has antioxidant and free-radical scavenging activity.

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Virgin coconut oil protects against liver damage in albino rats challenged with the anti-folate combination, trimethoprim-sulfamethoxazole

Abstract: The results of this study demonstrate that the active components of coconut oil had protective effects against the toxic effects induced by TMP-SMX administration, especially in the liver of rats.

Cited by 22 publications

References 19 publications

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Coconut Milk and Coconut Oil: Their Manufacture Associated with Protein Functionality

Evaluation of the safety profile and antioxidant activity of fatty hydroxamic acid from underutilized seed oil of Cyperus esculentus

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