Trimethoprim resistance in hospitals.

Abstract

RAUNO MANTYJARVI, MD, professor of clinical microbiology in Finland was similar to that in a London hospital just before plain trimethoprim was registered for use in Britain.

Trimethoprim resistance

“…SPREAD OF RESISTANCE The use of TMP, either alone or in combination with sulfonamides, appears to be an important factor in the development and spread of TMP resistance (24,43,58,70), particularly in a hospital setting (41,43). In outpatients, however, a relationship between consumption and the development of resistance is not always evident (44).…”

“…In industrialized countries, such as the United Kingdom and Finland, TMP resistance tends to be a problem in hospitals, particularly in geriatric units (4,41,43). In a hospital study in Finland, TMP resistance was found in 38% of urinary tract isolates (Pseudomonas spp.…”

“…In a hospital study in Finland, TMP resistance was found in 38% of urinary tract isolates (Pseudomonas spp. excluded) collected from a geriatric hospital but in only 9 to 12% of strains collected from two university central hospitals mainly for acutely ill patients (41). In geriatric units there is a need for indwelling urinary tract catheters and long-term treatment of urinary tract infections, which usually are associated with resistance problems (23,41,43).…”

Longitudinal survey of ATB resistance reversibility in children with AIDS of genocide survivors in Cambodia

“…was logically followed with less HIV related infections (4). Less antimicrobial agents use is possibly responsible for the phenomenon of the reversibility of antimicrobial resistance also in pathogens colonizing in the respiratory tracts of children with HIV on active antiretroviral therapy.…”

Emergence of trimethoprim resistance in fecal flora

“…After multipoint inoculation, plates were incubated at 35°C for 18 h (6). Resistance breakpoints used were 8 ,ug/ml for TMP and 512 ,g/ml for SMX (6). E. coli ATCC 25922 and Staphylococcus aureus ATCC 25923 were used as control strains.…”