2014
DOI: 10.1128/jvi.03603-13
|View full text |Cite
|
Sign up to set email alerts
|

TRIM5α and TRIM22 Are Differentially Regulated According to HIV-1 Infection Phase and Compartment

Abstract: The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5␣ and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5␣, TRIM22, and type I interferon (IFN-I)-inducible myxovirus resistance protein A (MxA) levels in peripheral blood mononuclear cells (PBMCs) during primary and chronic HIV-1 infection, with chronic infection samples being matched PBMCs and central nervous system… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
14
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 21 publications
(15 citation statements)
references
References 54 publications
1
14
0
Order By: Relevance
“…The tripartite motif (TRIM)-containing proteins have attracted enough attention to their multiple functions in different biological processes [1,2]. Especially in antiviral immunity, a number of TRIM proteins have been elucidated to exert crucial roles in response to virus infection recently [3,4]. Knockdown of TRIM15 decreased retinoic acid-inducible gene-I (RIG-I) induced interferon production and enhanced vesicular stomatitis virus (VSV) replication [5].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The tripartite motif (TRIM)-containing proteins have attracted enough attention to their multiple functions in different biological processes [1,2]. Especially in antiviral immunity, a number of TRIM proteins have been elucidated to exert crucial roles in response to virus infection recently [3,4]. Knockdown of TRIM15 decreased retinoic acid-inducible gene-I (RIG-I) induced interferon production and enhanced vesicular stomatitis virus (VSV) replication [5].…”
Section: Introductionmentioning
confidence: 99%
“…Overexpression of TRIM4 potentiated virus-triggered activation of interferon regulator factor (IRF) 3 and IFN-b induction, and finally mildly inhibited VSV replication [6]. Moreover, several TRIM proteins were proposed to restrict human immunodeficiency virus (HIV) or murine leukemia viruses (MLV) replication upon overexpression in vitro [3,5,7]. In addition to the antiviral activity to RNA virus, TRIM21 and TRIM5a were also found to exert their antiviral roles against DNA viruses [8].…”
Section: Introductionmentioning
confidence: 99%
“…TRIM22 was reported to be inducible by type 1 IFN in vitro [ 62 , 65 ]. The association between TRIM22 and type 1 IFN expression in vivo was recently identified in HIV studies [ 63 , 64 ]. TRIM22 was suggested as an antiviral effector in vitro and in vivo [ 63 , 64 ].…”
Section: Resultsmentioning
confidence: 99%
“…To date, the most intensively studied antiviral TRIM protein may be TRIM5α, especially to retrovirus [58]. Being one of its closest paralogs, TRIM22 was first identified independently by several laboratories to possess antiviral Fig.…”
Section: Discussionmentioning
confidence: 99%