TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway

Shi, Guangming; Lv, Chen; Yang, Zhipeng; T, Qin; Sun, Li; Pan, Peng; Wang, D

doi:10.4149/neo_2019_190106n21

Cited by 17 publications

(14 citation statements)

References 30 publications

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“…TRIM31 occupies center stage in human hepatocellular carcinoma by upregulating the mTORC1 signaling pathway (Guo et al, 2018). TRIM31 promotes proliferation, invasion, and migration of glioma cells via protein kinase B signaling pathway or by activating the nuclear factor κB (NF‐κB) pathway (Shi et al, 2019; Zhou et al, 2019). TRIM31 promotes invasion and metastasis in colorectal cancer by regulating chronic inflammation through the NF‐κB signaling pathway (H. Wang, Yao, Gong, & Zhang, 2018), but it is also a tumor suppressor, inhibiting malignant cancer growth of non‐small‐cell lung cancer (Li et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

Huang

Liu

Chen

et al. 2020

Cell Biology International

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NOD-like receptor protein 3 (NLRP3) is associated with age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells serve as the immune defense of macula, and their dysfunction causes clinically relevant changes in AMD. In the present study, oxidized low-density lipoprotein (ox-LDL) activated the NLRP3 inflammasome in human RPE cell line ARPE-19. Our data showed that the expression of NLRP3, interleukin-1β (IL-1β), and caspase-1 and the release of IL-1β in ARPE-19 cells were substantially increased by ox-LDL, whereas the addition of NLRP3 inhibitor INF39 dose-dependently reversed the effect of ox-LDL. Overexpression of tripartite motif-containing protein 31 (TRIM31) also suppressed the effect of ox-LDL in ARPE-19 cells. TRIM31 knockdown had similar effects with ox-LDL but INF39 could block the effect of TRIM31 knockdown. Moreover, TRIM31 could interact with NLRP3 in ARPE-19 cells. Overexpression of TRIM31 increased NLRP3 ubiquitination. In conclusion, the results propose that TRIM31 could enhance NLRP3 ubiquitination, therefore inhibiting NLRP3 inflammasome and pyroptosis in human RPE cells.

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Section: Introductionmentioning

confidence: 99%

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

Huang

Liu

Chen

et al. 2020

Cell Biology International

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“…This study identified differential DNA methylation associated with the herbicide glyphosate and its metabolite AMPA and developed a methylation index that accurately predicted urinary glyphosate concentration and tertile in an internal validation sample. Glyphosate- and AMPA-associated methylation occurred near genes associated with cancer ( SF3B2, 109 , 110 , 111 MSH4, 113 and TRIM31 117 , 118 , 119 ) and endocrine disruption ( ESR1 132 ), and AMPA was associated with greater epigenetic age acceleration. These results suggest that exposure to these common chemicals affects the epigenome, informing the hypothesis that glyphosate and/or AMPA exposure might elevate the risk for disease, including cancer.…”

Section: Discussionmentioning

confidence: 96%

“… 113 ERCC8 is also involved in DNA repair via transcription-coupled nucleotide excision repair and double-strand break repair. 114 , 115 , 116 Hypomethylation at TRIM31 , which has been shown to promote progression in a variety of tumor types, 117 , 118 , 119 was associated with AMPA. The AMPA-associated hypomethylation at the ESR1 promoter is fascinating, given the potential link between AMPA and breast cancer risk 23 , 32 and the potential for glyphosate-induced endocrine disruption.…”

Section: Discussionmentioning

confidence: 99%

Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women

Lucia

Huang

Pathak

et al. 2022

Environ Health Perspect

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Background: Glyphosate is the most commonly used herbicide in the world and is purported to have a variety of health effects, including endocrine disruption and an elevated risk of several types of cancer. Blood DNA methylation has been shown to be associated with many other environmental exposures, but to our knowledge, no studies to date have examined the association between blood DNA methylation and glyphosate exposure. Objective: We conducted an epigenome-wide association study to identify DNA methylation loci associated with urinary glyphosate and its metabolite aminomethylphosphonic acid (AMPA) levels. Secondary goals were to determine the association of epigenetic age acceleration with glyphosate and AMPA and develop blood DNA methylation indices to predict urinary glyphosate and AMPA levels. Methods: For 392 postmenopausal women, white blood cell DNA methylation was measured using the Illumina Infinium MethylationEPIC BeadChip array. Glyphosate and AMPA were measured in two urine samples per participant using liquid chromatography–tandem mass spectrometry. Methylation differences at the probe and regional level associated with glyphosate and AMPA levels were assessed using a resampling-based approach. Probes and regions that had an false discovery rate in of 1,000 subsamples of the study population were considered differentially methylated. Differentially methylated sites from the probe-specific analysis were combined into a methylation index. Epigenetic age acceleration from three epigenetic clocks and an epigenetic measure of pace of aging were examined for associations with glyphosate and AMPA. Results: We identified 24 CpG sites whose methylation level was associated with urinary glyphosate concentration and two associated with AMPA. Four regions, within the promoters of the MSH4 , KCNA6 , ABAT , and NDUFAF2 / ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA. The methylation index accurately predicted glyphosate levels in an internal validation cohort. AMPA, but not glyphosate, was associated with greater epigenetic age acceleration. Discussion: Glyphosate and AMPA exposure were associated with DNA methylation differences that could promote the development of cancer and other diseases. Further studies are warranted to replicate our results, determine the functional impact of glyphosate- and AMPA-associated differential DNA methylation, and further explore whether DNA methylation could serve as a biomarker of glyphosate exposure. https://doi.org/10.1289/EHP10174

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“…In addition, increased TRIM31 expression was associated with elevated p-Akt (S473), PCNA and E-cadherin expression. By using Akt agonists in TRIM31 -silenced cells or Akt antagonists in TRIM31-overexpressing cells, it was shown that TRIM31 mediates tumorigenesis through Akt signaling [ 95 ] ( Figure 2 a).…”

Section: Trim Proteins In Brain Tumorsmentioning

confidence: 99%

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Giannopoulou

Xanthopoulos

Piperi

et al. 2022

Cancers

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Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology to provide more promising diagnostic, prognostic, and therapeutic tools for gliomas. The tripartite motif-containing (TRIM) superfamily of proteins plays a key role in many physiological cellular processes, including brain development and function. Emerging evidence supports the association of TRIMs with a wide variety of cancers, exhibiting both an oncogenic as well as a tumor suppressive role depending on cancer type. In this review, we provide evidence of the pivotal role of TRIM proteins in gliomagenesis and exploit their potential as prognostic biomarkers and therapeutic targets.

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TRIM31 promotes proliferation, invasion and migration of glioma cells through Akt signaling pathway

Cited by 17 publications

References 30 publications

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3

Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

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