Trigonella foenum graecum seed polysaccharide coupled nano hydroxyapatite-chitosan: A ternary nanocomposite for bone tissue engineering

Zia, Iram; Mirza, Sumbul; Jolly, Reshma; Rehman, Abdur; Ullah, Rizwan; Shakir, Mohammad

doi:10.1016/j.ijbiomac.2018.11.059

Cited by 27 publications

(16 citation statements)

References 59 publications

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“…Thus, it can be deduced that the nHAp/ CHI/k-CGN nanocomposite have better mineralization ability and hence the ability to form a direct bond with the living bone when it is implanted in the body as compared to nHAp/ CHI nanocomposite. [23,24] In vitro degradation assessment Nanocomposite as a bone-implant should not only be biodegradable, but its rate of degradation should be compatible with the growth rate of the neo-tissue, in order to avoid any additional surgery for its removal after completion of its task of acting as templates for new tissue. [55] Hence, for understanding the in vivo degradation performance of the prepared nanocomposites, their in vitro degradation behavior was investigated using lysozyme enzyme.…”

Section: In Vitro Biomineralization Studymentioning

confidence: 99%

Nanocomposite Materials Developed from Nano‐hydroxyapatite Impregnated Chitosan/κ‐Carrageenan for Bone Tissue Engineering.

et al. 2022

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Herein, nano-hydroxyapatite impregnated chitosan/k-carrageenan (nHAp/CHI/k-CGN) nanocomposite was prepared through co-precipitation approach and was compared with nano-hydroxyapatite/chitosan (nHAp/CHI) nanocomposite for bone regeneration capability. The comparative assessment carried out through Scanning electron microscopy, Fourier transform infra-red spectroscopy, X-ray diffraction and mechanical testing revealed rough surface morphology, better interaction between the components, favorable crystallinity, and higher mechanical properties for the nHAp/CHI/k-CGN nanocomposite as compared to the bicomponent nanocomposite.Moreover, the in vitro biomineralization study showed increased deposition of apatite layer on nHAp/CHI/k-CGN nanocomposite as compared to nHAp/CHI nanocomposite. The cytocompatibility studies carried out using the MG-63 cell line revealed greater cell viability when cultured in the presence of nHAp/CHI/k-CGN nanocomposite as compared to nHAp/CHI. In addition, appropriate swelling ability, enhanced protein adsorption, and favorable degradation rate were also observed for the nHAp/CHI/k-CGN nanocomposite. All the results substantiate that nHAp/CHI/k-CGN nanocomposite could be a better candidate for bone regeneration.

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Section: In Vitro Biomineralization Studymentioning

confidence: 99%

Nanocomposite Materials Developed from Nano‐hydroxyapatite Impregnated Chitosan/κ‐Carrageenan for Bone Tissue Engineering.

et al. 2022

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“…25 The polysaccharide is classified as a bioactive natural polymer and is broadly used in biomedical applications due to its antioxidant, antiviral, antitumor and anti-inflammatory properties. 51 The hydroxyapatite-chitosan (HA-CS) nanocomposite and TFSP were synthesized via co-precipitation technique by Zia et al 122 The nanocomposite was proven suitable for biomedical applications due to its tremendous properties. The porosity of HA-CS nanocomposite reinforced with TFSP was 60.3 ± 0.17%, ie within the range of cancellous bone, 50-90%.…”

Section: Trigonella Foenum-graecum Seed Polysaccharidementioning

confidence: 99%

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Halim¹,

Hussein²,

Kandar

2021

IJN

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Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited.

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Section: Action On Bonementioning

confidence: 99%

“…Further, the zero-valent iron nanoparticles are synthesized by fenugreek extract and ferric chloride salt through the green method. The particle size of iron nanoparticle was found to be 11nm and was applied for antibacterial activity and the result reveals that [81] these nanoparticles are active against various strains of bacteria such as S. aureus and E. Coli [77].…”

Section: Biosynthesized Nano-particle Using Fenugreek Seeds Extracts mentioning

confidence: 99%

“…TFSP in nHA-CH increases the capacity of in vitro water absorption and protein adsorption and have potent antimicrobial property. Thus nHA-CH-TFSP is useful for bone implant [81]. Phytates, phosphorus tc.reported for their marked efficacy like6-C galactosyl-8-C-arabinoside, useful for their anti-diabetic effects against different types of cancers [34,54,55,57,72], whereas other secondary metabolites are useful for effect either alone or in the extract as a combination.…”

Section: Action On Bonementioning

confidence: 99%

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Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

2020

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Fenugreek seeds have widespread relations with Ayurveda, Unani, and Arabic medicine. The seeds were useful for the treatment and prevention of different ailments. Fenugreek (Trigonella foenum-graecum) or methi is from the Leguminosae family and are primarily known for its anti-diabetic and hypocholesterolemic activities. The germinated fenugreek seeds were used in the treatment of E.coli infection in Germany and France. The important phytoconstituents responsible for such medicinal applications are saponins, polyunsaturated fatty acids, galactomannans, trigonelline, and 4-hydroxy isoleucine. Flavonoids, apigenin 6,8-di-C-glucoside, apigenin-6-C-glucosyl-8-C-galactoside, 6-Cgalactosyl- 8-C-arabinoside are the chief ingredients of fenugreek seeds; responsible for reducing blood glucose while given to diabetic rats, whereas important flavones are epigenin, luteolin and vitexin. The other major bioactive components in fenugreek seeds are polyphenols like rhaponticin and isovitexin. Fenugreek seeds contain phosphorus and are categorized into different classes such as inorganic phosphorus, phospholipids, phytates, phosphor-proteins, and nucleic acid. Germinated seeds profusely filled with amino acids with amino acids, proteins, ascorbic acid, sugars. Further, this review shares information about the recent therapeutic intervention not covered earlier; on in vivo and in vitro and some clinical applications against certain interesting ailments other than older applications. This review includes certain nano delivery systems of Fenugreek seeds and their medicinal application.

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Trigonella foenum graecum seed polysaccharide coupled nano hydroxyapatite-chitosan: A ternary nanocomposite for bone tissue engineering

Cited by 27 publications

References 59 publications

Nanocomposite Materials Developed from Nano‐hydroxyapatite Impregnated Chitosan/κ‐Carrageenan for Bone Tissue Engineering.

Nanocomposite Materials Developed from Nano‐hydroxyapatite Impregnated Chitosan/κ‐Carrageenan for Bone Tissue Engineering.

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Recent Therapeutic Interventions of Fenugreek Seed: A Mechanistic Approach

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