Triglycerides and waist to height ratio are more accurate than visceral adiposity and body adiposity index to predict impaired fasting glucose

Elizalde-Barrera, César Iván; Rubio-Guerra, Alberto Francisco; Lozano-Nuevo, José Juan; Olvera-Gomez, Jose Luis

doi:10.1016/j.diabres.2019.05.019

Cited by 22 publications

(22 citation statements)

References 33 publications

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“…36 Furthermore, another study indicated that visceral adiposity was significantly associated with IFG, and isolated IFG had been shown to lead to hepatic IR. 37 Because patients may have undiagnosed IFG for an extended period of time, asymptomatic complications such as diabetic nephropathy can eventually develop. 38 Therefore, the findings of the present study may offer proof for prevention of early diabetic nephropathy via the improvement of the HTGW phenotype.…”

Section: <0001mentioning

confidence: 99%

Association Between Hypertriglyceridemic Waist Phenotype and Increased Urinary Albumin–Creatinine Ratio in Chinese Adults: The REACTION Study

Su¹,

Wang²,

Mu³

2020

DMSO

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The hypertriglyceridemic waist (HTGW) phenotype can predict cardiovascular disease (CVD) risk. Additionally, strong evidence indicates that elevated urinary albumincreatinine ratio (UACR) is associated with increased prevalence of CVD. However, few studies have explored the association between the HTGW phenotype and UACR. Patients and Methods: In this cross-sectional descriptive study, a total of 40,674 subjects (28,562 women and 12,112 men older than 40 years) were recruited from seven different geographic regional centres. The HTGW phenotype was defined as increased triglyceride levels (triglyceride ≥ 1.5 mmol/L for female and ≥2.0 mmol/L for male) and waist circumference (WC; WC ≥ 85 for female and WC ≥ 90 cm for male). Logistic regression analyses were performed to assess the relationship between UACR and the HTGW phenotype. Results: Subjects with the HTGW phenotype showed a more significant trend towards increased excretion of UACR [among all subjects, odds ratio (OR) = 1.303, 95% CI: 1.132-1.499, P < 0.001; among men, OR = 1.406, 95% CI: 1.057-1.870, P = 0.019; among women, OR = 1.268, 95% CI: 1.074-1.496, P = 0.005]. Furthermore, the stratified analysis showed that the OR for high-risk significantly increased in individuals in the HTGW group aged below 65 years, with 5.6 ≤ fasting blood glucose < 7.0 or 7.8 ≤ post-load blood glucose <11.1 mmol/L, 120 ≤ systolic blood pressure < 140 or 80 ≤ diastolic blood pressure < 90, 24 ≤ body mass index < 28 kg/m 2 , and estimated globular filtration rate > 90 mL/min per 1.73 m 2. Conclusion: This study has advanced the understanding of visceral obesity and our results supported the fact that the HTGW phenotype is associated with elevated UACR excretion among general Chinese adults.

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Section: <0001mentioning

confidence: 99%

Association Between Hypertriglyceridemic Waist Phenotype and Increased Urinary Albumin–Creatinine Ratio in Chinese Adults: The REACTION Study

Su¹,

Wang²,

Mu³

2020

DMSO

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“…33 In the context of adiponectin and T2DM or glucose homeostasis relationship, obesity-related traits is most likely a significant confounder. [34][35][36][37][38] Then, the pleiotropy of 18 remaining candidate IVs (Table S2) Figure 1 A directed acyclic graph representing the MR framework. Notes: IV1: The G associates with the X (P<5E-8); IV2: The G should not straightforwardly associate with Y; IV3: The G should not associate with any confounding factors.…”

Section: Adiponectin and Glucose Homeostasismentioning

confidence: 99%

Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study

Chen¹,

Bai²,

Long³

et al. 2020

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The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them. Materials and and Methods: Two-sample MR analyses and multiple sensitivity analyses were performed using the summary data from the ADIPOGen consortium, MAGIC Consortium, and a meta-analysis of GWAS with a considerable sample of T2DM (62,892 cases and 596,424 controls of European ancestry). We got eight valid genetic variants to predict the causal effect among adiponectin and T2DM and glucose homeostasis after excluding the probable invalid or pleiotropic variants. Results: Adiponectin was not associated with T2DM (odds ratio (OR) = 1.004; 95% confidence interval (CI): 0.740, 1.363) when using MR Egger after removing the invalid SNPs, and the results were consistent when using the other four methods. Similar results existed among adiponectin and HOMA-β, HOMA-IR, FI, FG. Conclusion: Our MR study revealed that adiponectin had no causal effect on T2DM and glucose homeostasis and that the associations among them in observational studies may be due to confounding factors.

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“…39 In this condition, simple and conveniently surrogate indices of VAT and insulin resistance are needed. The three novel metabolic indices VAI, LAPI, TyG have been proposed as markers of visceral adipose function and insulin resistance 9,40 and have been linked to cardiometabolic diseases, 9 impaired fasting glucose, 12 discrimination of prediabetes and diabetes, 13,14 metabolic syndrome 15 and Chronic Kidney Disease 16,17 in a cross-sectional study. VAI which combines both anthropometric and metabolic…”

Section: Discussionmentioning

confidence: 99%

“…Recently, three new indices, visceral adiposity index (VAI) and Triglycerides-glucose index (TyG), the lipid accumulation product index (LAPI), were proposed. These novel indices have been used as estimators of visceral adiposity dysfunction and lipid overaccumulation, 9,10 and these novel indices have been found to correlate with insulin resistance, 11 impaired fasting glucose, 12 discrimination of prediabetes and diabetes, 13,14 metabolic syndrome 15 and Chronic Kidney Disease. 16,17 However, there are few studies to compare the different predictive value of three novel indices for CKD, especially in the southern Chinese population, so our study aims to further explore which indices were superior to associate with CKD and identify individuals with CKD in the Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Novel Metabolic Indices in Estimation of Chronic Kidney Diseases in a Southern Chinese Population

Chen¹,

Wang²,

Wang³

et al. 2020

DMSO

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Triglycerides and waist to height ratio are more accurate than visceral adiposity and body adiposity index to predict impaired fasting glucose

Cited by 22 publications

References 33 publications

<p>Association Between Hypertriglyceridemic Waist Phenotype and Increased Urinary Albumin–Creatinine Ratio in Chinese Adults: The REACTION Study</p>

<p>Association Between Hypertriglyceridemic Waist Phenotype and Increased Urinary Albumin–Creatinine Ratio in Chinese Adults: The REACTION Study</p>

<p>Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study</p>

<p>Comparison of Novel Metabolic Indices in Estimation of Chronic Kidney Diseases in a Southern Chinese Population</p>

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