Triglyceride to high‐density lipoprotein cholesterol ratio predicts worse outcomes after acute ischaemic stroke

Deng, Qiwen; Wang, H.; Sun, Chao; Xing, Fang; Zhang, H.-Q.; Zuo, Lei; Gu, Zhen; Yan, Fuling

doi:10.1111/ene.13198

Cited by 40 publications

(46 citation statements)

References 22 publications

(26 reference statements)

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“…All adjusted for gender, age, BMI, hypertension, smoking, atherosclerosis, WBC, PLT, Hb, ALT, AST, Cr, UA, and TnT. 6 BioMed Research International association with the occurrence of ischemic [30], which is potentially the source of high TG/HDL-c ratio in type B AAD patients [31]. Although operation is still the most effective way to avoid in-hospital deaths in patients with AAD, other risk factors for the prediction of in-hospital mortality need to be considered.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Zhou

Yang

et al. 2020

BioMed Research International

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Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (inhospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55:00 ± 11:74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2:08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P = 0:983) and 3.17 (1.54-6.57, P = 0:001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.

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Section: Discussionmentioning

confidence: 99%

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Zhou

Yang

et al. 2020

BioMed Research International

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“…Four-group comparison was assessed using the χ 2 test, one-way analysis of variance(ANOVA) and Mann-Whitney U tests, as appropriate. Multivariate analysis adjustment for variables was performed for the correlation between the quartiles of plasma D-dimer level and poor outcome by logistic regression analysis, which used methods from previous studies [ 24,25] . Results were expressed as adjusted odds ratios (OR) with the corresponding 95% confidence intervals (CIs).…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma D-dimer level is associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

Yao

Tian

et al. 2019

Preprint

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Background: Elevated level of plasma D-dimer increases the risk of ischemic stroke, stroke severity and progression of stroke status, but the association between plasma D-dimer level and functional outcome is unclear. The aim of this study is to investigate whether Plasma D-dimer level is a determinant of short-term poor functional outcome in patients with acute ischemic stroke (AIS).Methods: This prospective study included 877 Chinese patients with AIS admitted to Renmin Hospital of Wuhan University within 72 hours of symptom onset. Patients were categorized per plasma D-dimer level: Quartile 1( 0.24 mg /L), Quartile 2 (0.25-0.56 mg /L), Quartile 3 (0.57-1.78 mg /L), and Quartile 4 ( 1.78mg /L). Each patient's medical record was reviewed, and demographic, clinical, laboratory and neuroimaging information was abstracted. Functional outcome at 90 days was assessed with the modified Rankin Scale (mRS). Results: Of 877 patients were included (mean age, 64 years; male, 68.5%), poor outcome was present in 302 (34.4%) patients. After adjustment for potential confounding variables, higher plasma D-dimer level on admission was associated with poor outcome (adjusted odds ratio aOR 2.257, 95% CI1.349-3.777 for Q4:Q1; P trend = 0.004). According to receiver operating characteristic (ROC) analysis, the best discriminating factor was a plasma D-dimer level 0.315 mg/L for pour outcome area under the ROC curve (AUC) 0.657; sensitivity 83.8%; specificity 41.4%. Conclusion: Elevated plasma D-dimer level on admission was significantly associated with increased poor outcome after admission for AIS, suggesting the potential role of plasma D-dimer as a predictive marker for short-term poor outcome in patients with AIS.

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“…Extracranial/transcranial Doppler ultrasound and echocardiography were conducted from days 2 to 7 after admission if necessary. Other diagnostic procedures including arteriography, chest radiograph, electroencephalogram, and laboratory tests were conducted/repeated as indicated until discharge for the individuals . All subjects were followed up for 3 months after AIS and lipid levels on admission were available.…”

Section: Methodsmentioning

confidence: 99%

The total cholesterol to high‐density lipoprotein cholesterol as a predictor of poor outcomes in a Chinese population with acute ischaemic stroke

Chen

Sun

et al. 2017

Clinical Laboratory Analysis

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Triglyceride to high‐density lipoprotein cholesterol ratio predicts worse outcomes after acute ischaemic stroke

Abstract: A lower TG/HDL-C was independently associated with death and worse outcome at 3 months in AIS.

Cited by 40 publications

References 22 publications

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Elevated plasma D-dimer level is associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

The total cholesterol to high‐density lipoprotein cholesterol as a predictor of poor outcomes in a Chinese population with acute ischaemic stroke

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