Triglyceride/High-Density Lipoprotein Cholesterol Ratio Is Associated with In-Hospital Mortality in Acute Type B Aortic Dissection

Abstract

Background. Triglyceride/high-density lipoprotein cholesterol (TG/HDL-c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL-c ratio and in-hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL-c ratio) and independent (inhospital mortality) variables. TG/HDL-c ratio was determined as a division of TG levels by HDL-c levels. Results. Of 523 patients in the study, we found a mean age of 55:00 ± 11:74 years, 15.68% of them being female. A fully-adjusted model revealed a positive relationship between TG/HDL-c ratio and in-hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2:08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580-1.26, P = 0:983) and 3.17 (1.54-6.57, P = 0:001), respectively. Conclusions. The TG/HDL-c ratio and in-hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in-hospital mortality when it is less than 2.05.

High serum VE-cadherin and vinculin concentrations are markers of the disruption of vascular integrity during acute aortic dissection

“…(34) In addition, high serum HDL-C and TG concentrations are considered to be the risk factors for cardiovascular disease. (35)(36)(37) Further multiple logistic regression analysis showed that the serum VEC and Vcn concentrations were associated with the prevalence of acute preoperative complications in patients with AAD. Of note, compared with patients with refractory pain, the adjusted OR for VEC concentration in patients without refractory pain increased to 1.172.…”

Prevalence of the Metabolic Syndrome in Patients With Type B Aortic Dissection 

“…Low HDL-cholesterol: serum HDL-cholesterol < 1.0 mmol/l (40 mg/dl) in men or < 0.9 mmol/l (50 mg/dl) in women. 5. High fasting glucose: fasting serum glucose ≥ 6.1 mmol/l (110 mg/dl).…”

“…In uence factors associated with TBAD include hypertension, diabetes mellitus (DM), obesity, and hyperlipidemia, which are also common components of MS. As estimated, approximately 80% of patients who develop an aortic dissection have hypertension, 31% of patients have atherosclerosis [3][4]. Nevertheless, the role of association diabetes mellitus, obesity, triglyceride and high-density lipoprotein cholesterol in TBAD remains unclear with controversial or scarce research ndings [5].…”

Ischemia-Modified Albumin As a Marker for Acute Aortic Dissection: A Prospective Observational Study

“…Acute aortic dissection (AAD) is a life-threatening vascular disease with a high death rate and morbidity [1,2]. An untreated AAD can lead to increased mortality of 1-2% per hour after symptom onset.…”