Triglyceride Glucose Index is Related with the Risk of Mild Cognitive Impairment in Type 2 Diabetes

Abstract

Background The triglyceride glucose (TyG) index reflects insulin resistance; the latter being associated with mild cognitive impairment (MCI). Objective To investigate the clinical value of the TyG index to identify MCI in patients living with type 2 diabetes (T2D) using a cross-sectional study. Methods This cross-sectional study was performed on 517 patients with T2D. The diagnosis of MCI was based on criteria established by the National Institute on Aging-Alzheimer’s Association workgroup, and patients were divided into the MCI group and the normal cognitive function (NCF) group. The logistic regression analysis determines whether the TyG index is related to MCI. Subsequently, we constructed the receiver operating characteristic curve (ROC) and calculated the area under the curve (AUC). The nomogram model of the influence factor was established and verified. Results Compared to the type 2 diabetes-normal cognitive function (T2D-NCF) group, the MCI subjects were olderand had higher TyG indexes, lower cognitive scores, and lower education levels (p < 0.01). After adjusting for the confounders, the TyG index was associated with MCI (OR = 7.37, 95% CI = 4.72–11.50, p < 0.01), and TyG-BMI was also associated with MCI (OR = 1.02, 95% CI = 1.01–1.02, p<0.01). The TyG index AUC was 0.79 (95% CI = 0.76–0.83). The consistency index of the nomogram was 0. 83[95% CI (0. 79, 0. 86)]. Conclusion Our results indicate that the TyG index and TyG-BMI are associated with MCI in T2D patients, and the TyG index is an excellent indicator of the risk of MCI in T2D patients. The nomogram incorporating the TyG index is useful to predict MCI risk in patients with T2D.

Association Between Metabolic Syndrome and Decline in Cognitive Function: A Cross-Sectional Study

“…20,21 Another study found that in participants with type 2 diabetes, the TyG index could be used to predict the risk of developing mild cognitive decline. 22 In the present study, we found that participants with MetS had a 50% increase in odds of poor speed of reaction scores, although this change was not statistically significant . This finding is consistent with that of a previous study that reported an association between MetS and poor speed of reaction in the elderly.…”

“… 20 , 21 Another study found that in participants with type 2 diabetes, the TyG index could be used to predict the risk of developing mild cognitive decline. 22 …”

Association Between Triglyceride Glucose Index with Cognitive Impairment and Dementia in Adult Population: A Meta-Analysis

“…1. Consequently, a total of ten studies were deemed suitable for subsequent meta-analysis [18][19][20][21][22][23][24][25][26][27].…”

“…Overall, ten observational studies, including one prospective cohort study [26], three retrospective cohort studies [19,20,23], and six cross-sectional studies [18,21,22,24,25,27], were included in the meta-analysis. The characteristics of the included studies are summarized in ▶ table 1.…”

“…On the other hand, observational studies have further established a correlation between the TyG index and an elevated occurrence and unfavorable prognosis of cardiovascular diseases [17]. Although several observational studies have suggested a potential association between TyG index and cognitive dysfunction [18][19][20][21][22][23][24][25][26][27], a summarized effect for the association in a meta-analysis is still lacking. Moreover, it remains unknown whether the potential association between TyG index and cognitive dysfunction could be modified by age, sex, or diabetic status of the participants.…”