Triglyceride Glucose–Body Mass Index Is a Reliable Indicator of Bone Mineral Density and Risk of Osteoporotic Fracture in Middle-Aged and Elderly Nondiabetic Chinese Individuals

Abstract

(1) Background: This study aimed to investigate the relationship of triglyceride glucose–body mass index (TyG-BMI) with bone mineral density (BMD), femoral neck geometry, and risk of fracture in middle-aged and elderly Chinese individuals. (2) Methods: A total of 832 nondiabetic individuals were selected from the prospective population-based HOPE cohort. All individuals underwent DXA for assessment of BMD at the lumbar spine, femoral neck, and total hip, as well as femoral neck geometry. The 10-year probabilities of both major osteoporotic (MOFs) and hip fractures (HFs) were calculated. (3) Results: Cortical thickness, compression strength index, cross-sectional moment of inertia, cross-sectional area, section modulus, and 25(OH)D levels were significantly lower in women (all p < 0.001). The presence of osteoporosis was related to age, BMI, BMD and femoral neck geometry, TyG-BMI, MOF, and HF. TyG-BMI was positively correlated with BMD. In men, TyG-BMI showed significant negative correlation with HF but not with MOF, the correlation exists only after adjusting for other variables in women. Femoral neck geometries were significantly impaired in individuals with low TyG-BMI. (4) Conclusion: TyG-BMI is positively associated with BMD and geometry, and negatively associated with risk of fracture in nondiabetic middle-aged and elderly Chinese men and women.

Association between triglyceride glucose index and total bone mineral density: a cross-sectional study from NHANES 2011–2018

“…It was found that IR evaluated by TyG and TyG-related indices was significantly positively correlated with BMD among Americans. This is consistent with previous studies, such as an ongoing prospective study that found TyG-BMI was positively related to BMD and geometry in non-diabetic middle-aged and elderly Chinese individuals 29 . Moreover, a single-center retrospective study discovered that IR was positively correlated with BMD in postmenopausal women, as well as a protective factor for OP 12 .…”

Influence of age on the association between the triglyceride-glucose index and all-cause mortality in patients with cardiovascular diseases

“…Fasting TGI may have a better predictive value than non-fasting TGI. Although the interaction between TGI and fasting state as well as BMI in the present study was not significant, many studies have explored the predictive value of combining TGI with other markers such as TGI combining with BMI [ 69 ]. Therefore, other factors related to TGI should also be considered before the usage of TGI in clincial practice.…”

Insulin resistance is associated with the presence and severity of retinopathy in patients with type 2 diabetes

“…As a derivative of the TyG index, recent studies have found that TyG‐BMI is an independent risk factor for the prevalence of hypertension and that TyG‐BMI may predict the severity of coronary artery disease 39,40 . In addition, TyG‐BMI was associated with association between hyperuricemia, hepatic steatosis, and osteoporosis has also been confirmed in patients with type 2 diabetes 41–43 …”

“…39,40 In addition, TyG-BMI was associated with association between hyperuricemia, hepatic steatosis, and osteoporosis has also been confirmed in patients with type 2 diabetes. [41][42][43]…”