“…The morning peak of onset [1,2,5] seems to be slightly blunted in trigger-related infarctions [28], but it remains unclear whether the risk that some external event will trigger a myocardial infarction varies throughout the day, or during the week [52 -54] or year [54,55]. Besides gender differences observed in this metaanalysis, some studies provided support for the possibility that particular triggers have varying importance in different patient subgroups according to infarction site [34] or infarction type [31]. Furthermore, although it is difficult to assess an individual's reactivity to emotional stress, there is some evidence to suggest that patients with lower levels of educational attainment [33] are also at greater risk that emotional stress culminates in an acute myocardial infarction.…”