Triggered doxorubicin release using redox-sensitive hyaluronic acid-g-stearic acid micelles for targeted cancer therapy

Jeong, Gyu-Seob; Jeong, Young‐Il; Nah, Jae‐Woon

doi:10.1016/j.carbpol.2019.01.018

Cited by 43 publications

(14 citation statements)

References 32 publications

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“…Therefore, in order to kill tumor cells, it is inevitable to elevate the concentration of drugs inside tumor cells (Chen et al, 2016). It is well known that tumor cells usually overexpress specific receptors on their membranes, which are potential targets for select ligands, such as antibodies (Dumont et al, 2019;Liu et al, 2019), transferrin (Ke and Xiang 2018;Venkatesan et al, 2019), hyaluronic acid (Jeong et al, 2019;Wang et al, 2019), etc. By coupling these ligands onto the surface of nancarriers, their affinity toward tumor cells can be dramatically improved, thereby increasing the intratumor accumulation of chemotherapeutics via receptor-mediated internalization.…”

Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms

Wang

Zhang

et al. 2020

Drug Delivery

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Shen (2020) Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms, Drug Delivery, 27:1, 128-136, ABSTRACTReceptor-mediated active targeting and tumor microenvironment responsive systems from polymeric micelles have been studied for rapid cellular internalization and triggered drug release. Previously we have constructed redox-responsive polymeric micelles composed of vitamin E succinate conjugated hyaluronic acid (HA-ss-TOS), which are able to actively target CD44 proteins and quickly release loaded drugs upon exposure to high levels of glutathione (GSH) in tumor cells. In the present study, we found that despite different cellular internalization mechanisms, micelles showed strong antineoplastic effects on 4T1 and B16F10 cells due to redox responsiveness. HA-ss-TOS-PTX micelles exhibited an excellent tumor targeting ability and prolonged retention time compared to Taxol in vivo. In addition, a superior antitumor effect was achieved compared to PTX-loaded insensitive micelles (HA-TOS-PTX) and Taxol. Our results revealed that PTX-loaded HA-ss-TOS micelles could enhance the antineoplastic efficacy of PTX for breast cancer and melanoma treatment and, thus, deserve further attention. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms

Wang

Zhang

et al. 2020

Drug Delivery

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“…49 Moreover, the relatively low CMC was beneficial for maintaining the stability of polymeric micelles in blood circulation before reaching the target sites. 26…”

Section: Critical Micelle Concentration (Cmc)mentioning

confidence: 99%

“…21 Moreover, HA possesses a selective binding affinity to receptors, such as cluster determinant 44 (CD44) receptor, that are overexpressed within numerous tumors and thus can act as a ligand for active tumor targeting. 22,23 Based on the strengths mentioned above, a variety of hydrophobic agents, such as deoxycholic acid, 24 poly(L-histidine) 25 and stearic acid, 26 have been chemically conjugated to the backbones of HA to assemble into micelles for targeted delivery of anticancer drugs. However, the aggregation and saturation of receptors might be nonnegligible blocking factors for CD44-mediated internalization, resulting in compromised targeting efficiency.…”

Section: Introductionmentioning

confidence: 99%

<p>Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy</p>

Yang¹,

Li²,

Chen³

et al. 2020

IJN

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Poor site-specific delivery and insufficient intracellular drug release in tumors are inherent disadvantages to successful chemotherapy. In this study, an extraordinary polymeric micelle nanoplatform was designed for the efficient delivery of paclitaxel (PTX) by combining dual receptor-mediated active targeting and stimuli response to intracellular reduction potential. Methods: The dual-targeted redox-sensitive polymer, folic acid-hyaluronic acid-SS-vitamin E succinate (FHSV), was synthesized via an amidation reaction and characterized by 1 H-NMR. Then, PTX-loaded FHSV micelles (PTX/FHSV) were prepared by a dialysis method. The physiochemical properties of the micelles were explored. Moreover, in vitro cytological experiments and in vivo animal studies were carried out to evaluate the antitumor efficacy of polymeric micelles. Results: The PTX/FHSV micelles exhibited a uniform, near-spherical morphology (148.8 ± 1.4 nm) and a high drug loading capacity (11.28% ± 0.25). Triggered by the high concentration of glutathione, PTX/FHSV micelles could quickly release their loaded drug into the release medium. The in vitro cytological evaluations showed that, compared with Taxol or single receptor-targeted micelles, FHSV micelles yielded higher cellular uptake by the dual receptor-mediated endocytosis pathway, thus leading to significantly superior cytotoxicity and apoptosis in tumor cells but less cytotoxicity in normal cells. More importantly, in the in vivo antitumor experiments, PTX/FHSV micelles exhibited enhanced tumor accumulation and produced remarkable tumor growth inhibition with minimal systemic toxicity. Conclusion: Our results suggest that this well-designed FHSV polymer has promising potential for use as a vehicle of chemotherapeutic drugs for precise cancer therapy.

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“…Compared with pentaerythritol as the core polymer [21,22], a redox-sensitive polymer with better performance, namely adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)] 4 (AD-[P(LA-co-GA)-SS-mPEG] 4 ), was designed as a drug delivery material for DOX delivery and release (Scheme 1). between cancer cells (10 mM) and normal tissue (2 µM), polymer micelles with disulfide bonds are commonly used to control the release of anticancer drugs, as they allow the drug to be released under certain conditions [13][14][15].…”

Section: Of 13mentioning

confidence: 99%

“…Glutathione (GSH) is one of the most abundant tripeptide molecules containing thiol groups in cells, which can be involved in the cleavage of disulfide bonds in organisms. Since the concentration of GSH is significantly different between cancer cells (10 mM) and normal tissue (2 µM), polymer micelles with disulfide bonds are commonly used to control the release of anticancer drugs, as they allow the drug to be released under certain conditions [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

Guo

Wen

et al. 2019

Nanomaterials

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A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4 with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential.

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Triggered doxorubicin release using redox-sensitive hyaluronic acid-g-stearic acid micelles for targeted cancer therapy

Cited by 43 publications

References 32 publications

Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms

Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanisms

<p>Dual Receptor-Targeted and Redox-Sensitive Polymeric Micelles Self-Assembled from a Folic Acid-Hyaluronic Acid-SS-Vitamin E Succinate Polymer for Precise Cancer Therapy</p>

Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

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