Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

Li, Meng; Guo, Juan; Wen, Weiqiu; Chen, Jem-Kun

doi:10.3390/nano9040547

Cited by 12 publications

(9 citation statements)

References 34 publications

(43 reference statements)

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“…The in vitro cytotoxicity profiles of the blank CS‐NBCF micelles and DOX/CS‐NBCF micelles were evaluated against mouse embryonic fibroblasts (NIH‐3T3) cells and human breast cancer (MCF‐7) cells by the Cell Counting Kit‐8 (CKK‐8) assay, respectively 27 . NIH‐3T3 and MCF‐7 cells were seeded in 96‐well plates in 80 μl medium containing 10% (v/v) fetal bovine serum and 1% (w/v) penicillin–streptomycin at 37°C in a humidified 5% CO 2 ‐95% air atmosphere.…”

Section: Methodsmentioning

confidence: 99%

Hypoxia‐sensitive micelles based on amphiphilic chitosan derivatives for drug‐controlled release

Chen

Wen

Guo

2021

Polymers for Advanced Techs

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Natural chitosan (CS) is composed of a larger hydrophilic skeleton with great biocompatibility. A hypoxia sensitive amphiphilic conjugate (CS‐NBCF) was synthesized by conjugating CS with nitrobenzyl chloroformate (NBCF). Subsequently, nano micelles with high stability (CMC = 0.0030 mg/ml) were formed by self‐assembly of the polymers in deionized water. The hypoxia‐responsive function was demonstrated by examining the size variations of polymeric micelles under the hypoxia conditions. Doxorubicin (DOX) was encapsulated into the micellar core, the drug loading and encapsulation efficiency of DOX were 15.0% and 52.6%, respectively. The in vitro release experiments showed that DOX could be released rapidly in hypoxic environment, and the release amount was up to 68% in 24 h. It was found from the cytotoxicity experiment that that the toxicity of the blank micelles was low, while DOX‐loaded micelles exhibited a good anti‐cancer effect under hypoxic conditions, and the cell inhibition rate of MCF‐7 was high up to 63%. As a result, the demonstrated properties endowed as‐developed polymeric micelles with promising application as drug delivery system in tumor treatment.

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Section: Methodsmentioning

confidence: 99%

Hypoxia‐sensitive micelles based on amphiphilic chitosan derivatives for drug‐controlled release

Chen

Wen

Guo

2021

Polymers for Advanced Techs

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“…Nanomaterials responsive to photothermal stimuli generate heat to destroy tumor cells in response to near-infrared (NIR) light irradiation [47][48][49][50]. Drug delivery nanoplatforms that can perform drug release in response to a redox reaction or specific enzyme have also been developed [51][52][53][54][55][56][57][58][59][60][61][62] (Table 2). Gelatin-encapsulated magnetic nanoparticle [63] The anticancer DDS that can react with enzymes and control the release of DOX was developed by using cystamine-modified gelatin [63].…”

Section: Why Is a "Smart" Nanocarrier Needed For The Treatment Of Can...mentioning

confidence: 99%

Pharmaceutical Aspects of Nanocarriers for Smart Anticancer Therapy

Hwang

Chakraborty

et al. 2021

Pharmaceutics

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Drug delivery to tumor sites using nanotechnology has been demonstrated to overcome the drawbacks of conventional anticancer drugs. Altering the surface shape and geometry of nanocomposites alters their chemical properties, which can confer multiple attributes to nanocarriers for the treatment of cancer and their use as imaging agents for cancer diagnosis. However, heterogeneity and blood flow in human cancer limit the distribution of nanoparticles at the site of tumor tisues. For targeted delivery and controlled release of drug molecules in harsh tumor microenvironments, smart nanocarriers combined with various stimuli-responsive materials have been developed. In this review, we describe nanomaterials for smart anticancer therapy as well as their pharmaceutical aspects including pharmaceutical process, formulation, controlled drug release, drug targetability, and pharmacokinetic or pharmacodynamic profiles of smart nanocarriers. Inorganic or organic-inorganic hybrid nanoplatforms and the electrospinning process have also been briefly described here.

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“…Their self-assembled micelles were further developed to be platforms for anticancer drug delivery. To be specific, poly(lactic- co -glycolic acid) (PLGA) and poly(ethylene glycol) monomethyl ether (mPEG), as hydrophobic and hydrophilic segments, respectively, have the advantages of excellent biodegradability and compatibility [ 27 ]. Poly( N,N’ -diethylaminoethyl methacrylate) (PDEAEMA) is hydrophobic in neutral or alkaline conditions, while become to be hydrophilic in acidic medium due to the protonation of amino group in PDEAEMA.…”

Section: Introductionmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

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Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery

Cited by 12 publications

References 34 publications

Hypoxia‐sensitive micelles based on amphiphilic chitosan derivatives for drug‐controlled release

Hypoxia‐sensitive micelles based on amphiphilic chitosan derivatives for drug‐controlled release

Pharmaceutical Aspects of Nanocarriers for Smart Anticancer Therapy

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

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