Trigeminal neuralgia: A new therapy?

Collet, Corinne; Haen, P.; Laversanne, S.; Brignol, Liliane Dutra; Thiéry, G.

doi:10.1016/j.mehy.2013.10.010

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…That the use of adipose-derived MSCs in an animal model of hind paw neuropathic pain resulted in a decrease in the proinflammatory cytokine interleukin (IL)-1β in the lesioned nerve. 17,18 1.6. Surgical manoeuvres Surgical therapy should be considered if medical treatment fails or cannot be tolerated.…”

Section: Stem Cell Transplantationmentioning

confidence: 99%

Management of Trigeminal Neuralgia

Chaudhry¹

2021

JPBS

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Trigeminal Neuralgia (TN) is orofacial pain restricted to one or more divisions of the trigeminal nerve Attacks of intense, electric shock-like facial pain can occur without warning or be triggered by touching specific areas of the face by movements, brushing, laughing or following emotional stimuli. The exact cause of trigeminal neuralgia is not fully elucidated, a blood vessel is often found compressing the nerve. TN dramatically reduces the quality of life of affected individuals not only due to pain attacks but also to other disease-associated comorbidities, such as anxiety and depression. The Therapy used is often conservative with variable results

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Section: Stem Cell Transplantationmentioning

confidence: 99%

Management of Trigeminal Neuralgia

Chaudhry¹

2021

JPBS

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“…Fat grafting demonstrated a promising result in the treatment of neuropathic pain in patients affected by peripheral neuralgia, specifically in occipital, 14 pudendal, 15 and trigeminal neuralgia. 16,17 In 2009, Klinger et al 14 used fat grafting (Coleman’s technique) in a patient affected by postsurgical, chronic, drug-resistant occipital neuralgia, within the clinically painful affected area. According to the VAS score and to the Neck Pain Disability Index, a steady improvement was observed at 1-year follow-up.…”

Section: Peripheral Neuralgiamentioning

confidence: 99%

“…Fat grafting was also found to be beneficial in the treatment of trigeminal neuralgia. 16,17 Collet et al 17 published a case report in 2013 on a patient suffering from essential trigeminal neuralgia of right V3 (30–35 pain episodes a day) previously treated without success with carbamazepine, gabapentin, and amitriptyline at the time of consult. The labial and cheek region were treated with fat grafting (Coleman’s technique).…”

Section: Peripheral Neuralgiamentioning

confidence: 99%

The Role of Fat Grafting in Alleviating Neuropathic Pain: A Critical Review of the Literature

Alessandri‐Bonetti

Egro

Persichetti

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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Background: Neuropathic pain is one of the more severe types of chronic pain and presents a great challenge as response to medical therapy remains often unpredictable. With the opioid epidemic and the search for ways to avoid narcotics, physicians are seeking other modalities to treat neuropathic pain. In recent years, surgeons have explored various surgical avenues to improve outcomes. The aim of this review was to evaluate the current clinical evidence regarding the efficacy of fat grafting for the treatment of neuropathic pain. Methods: A critical review was conducted to examine the current clinical evidence of fat grafting as a therapy for neuropathic pain caused by neuromas, peripheral neuralgia, migraine and headaches, neuropathic scar pain, and postmastectomy pain syndrome. Results: The precise mechanism role of fat grafting in modulating neuropathic pain remains unclear, but it appears to reduce pain levels through the anti-inflammatory effects of adipose-derived stem cells and mechanical cushioning by fat. Conclusions: Fat grafting is an emerging therapy for chronic neuropathic pain of various etiologies. Although promising results have been reported, sample size and level of evidence of current studies are low. The encouraging results, however, are worthy of further clinical and scientific study. The minimally invasive nature of fat grafting and favorable risk profile make this an attractive therapy for neuropathic pain.

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