Triclosan inhibition of acute and chronic inflammatory gene pathways

Barros, Silvana P.; Wirojchanasak, Sodsi; Barrow, David A.; Panagakos, Fotinos; DeVizio, William; Offenbacher, Steven

doi:10.1111/j.1600-051x.2010.01548.x

Cited by 42 publications

(44 citation statements)

References 29 publications

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“…Associations between TCS exposure and reproductive outcomes in humans have not been studied, although TCS is thought to have anti-inflammatory properties (Barros et al, 2010; Elwood et al, 2007; Modeer et al, 1996; Mustafa et al, 2000; Wallet et al, 2013). Given that inflammation is a potential factor in preterm birth (Bastek et al, 2011), we might expect a possible protective relationship between urinary TCS concentrations and this outcome.…”

Section: Introductionmentioning

confidence: 99%

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Watkins

Ferguson

Toro

et al. 2015

International Journal of Hygiene and Environmental Health

192

112

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Phenols and parabens are used in a multitude of consumer products resulting in ubiquitous human exposure. Animal and in vitro studies suggest that exposure to these compounds may be related to a number of adverse health outcomes, as well as potential mediators such as oxidative stress and inflammation. We examined urinary phenol (bisphenol A (BPA), triclosan (TCS), benzophenone-3 (BP-3), 2,4-dichlorophenol (24-DCP), 2,5-dichlorophenol (25-DCP)) and paraben (butyl paraben (B-PB), methyl paraben (M-PB), propyl paraben (P-PB)) concentrations measured three times during pregnancy in relation to markers of oxidative stress and inflammation among participants in the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) project. Serum markers of inflammation (c-reactive protein (CRP), IL-1β, IL-6, IL-10, and tumor necrosis factor-α (TNF-α)) were measured twice during pregnancy (n=105 subjects, 187 measurements) and urinary markers of oxidative stress (8-hydroxydeoxyguanosine (OHdG) and isoprostane) were measured three times during pregnancy (n=54 subjects, 146 measurements). We used linear mixed models to assess relationships between natural log-transformed exposure and outcome biomarkers while accounting for within individual correlation across study visits. After adjustment for urinary specific gravity, study visit, maternal pre-pregnancy BMI, and maternal education, an interquartile range (IQR) increase in urinary BPA was associated with 21% higher OHdG (p=0.001) and 29% higher isoprostane (p=0.0002), indicating increased oxidative stress. The adjusted increase in isoprostane per IQR increase in marker of exposure was 17% for BP-3, 27% for B-PB, and 20% for P-PB (all p<0.05). An IQR increase in triclosan (TCS) was associated with 31% higher serum concentrations of IL-6 (p=0.007), a pro-inflammatory cytokine. In contrast, IQR increases in BP-3 and B-PB were significantly associated with 16% and 18% lower CRP, a measure of systemic inflammation. Our findings suggest that exposure to BPA, select parabens, and TCS during pregnancy may be related to oxidative stress and inflammation, potential mechanisms by which exposure to these compounds may influence birth outcomes and other adverse health effects, but additional research is needed.

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Section: Introductionmentioning

confidence: 99%

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Watkins

Ferguson

Toro

et al. 2015

International Journal of Hygiene and Environmental Health

192

112

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show abstract

“…Finally, exposure to some PCB congeners appears to affect the risk of non-Hodgkin lymphoma [105]. [106][107][108][109][110][111][112][113][114][115][116]. The categories include products from antimicrobial soap (triclosan), naturally occurring phytoestrogens in food (genistein), antimollusk (tributyltin) and antifungal (vinclozolin) compounds, drugs (valproate), mycotoxins (zearalenone), and industrial organics (acetaldehyde and nonylphenol).…”

Section: Information On Other Edcsmentioning

confidence: 97%

Effects of Endocrine Disrupters on Immune Function and Inflammation

Dietert¹

2015

Endocrine Disruption and Human Health

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“…These include delivering (a) redox agents that raise the local Eh in the periodontal pocket [44], (b) novel anti-inflammatory agents such as resolvins or lipoxins that promote tissue healing while also reducing the flow of GCF [45,46], which in turn, denies the microbiota access to factors essential for their growth, and (c) antimicrobial agents in oral care products that inhibit bacterial proteases at sub-lethal concentrations [43]. It has been noted that Triclosan, which has been widely formulated into dentifrices and mouthwashes, is both antimicrobial, antimetabolic (inhibitory to bacterial sugar metabolism and protease activity), and anti-inflammatory [47,48].…”

Section: Prevent the Growth Of Proteolytic And Anaerobic Subgingival mentioning

confidence: 98%

Dental plaque as a biofilm and a microbial community—Implications for treatment

Marsh

Head

DeVine

2015

Journal of Oral Biosciences

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Triclosan inhibition of acute and chronic inflammatory gene pathways

Abstract: Anti-inflammatory effects were found in this exploratory survey, including suppression of microbial-pathogen recognition pathway molecules and the suppression of acute and chronic mediators of inflammation.

Cited by 42 publications

References 29 publications

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Associations between urinary phenol and paraben concentrations and markers of oxidative stress and inflammation among pregnant women in Puerto Rico

Effects of Endocrine Disrupters on Immune Function and Inflammation

Dental plaque as a biofilm and a microbial community—Implications for treatment

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