Effects of Endocrine Disrupters on Immune Function and Inflammation

Dietert, Rodney R.

doi:10.1016/b978-0-12-801139-3.00014-4

Cited by 5 publications

(4 citation statements)

References 116 publications

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“…Kronik inflamasyon, uzun süreli (haftalar veya aylar) aktif inflamasyonla birlikte doku yıkımı ve doku onarımının aynı anda bir süreçtir. Akut inflamasyonda yaralanma bölgesine ağırlıklı olarak nötrofilik lökositlerin göçü gerçekleşirken, monositler ve makrofajlar, kronik inflamasyonda birincil hücrelerdir (Dietert, 2015;Stankov, 2012).…”

Section: Oksidatif Stres Ve İnflamasyonunclassified

“…BF'nin, sendai virüsü ile enfekte edilmiş Raw264.7 hücrelerinin interferon-β (IFN-β) ekspresyonu inhibe ettiği ve antiviral aktivite kaybına yol açtığı gösterilmiştir. Bu sonuçlar, EB'lerin enfeksiyona karşı bağışıklığı azaltabileceğini göstermektedir (Dietert, 2015).…”

Section: Eb'ler Dokulardaunclassified

“…Bisfenol A gibi EB'ler veya fitalatlar çok düşük dozlarda bile bir yanıt oluşturabilir. Oysa yanıt çok daha yüksek dozlarda zayıflar, bu da doğrusal olmayan, ters U-şekilli doz-yanıt eğrileri ile sonuçlanır (Dietert, 2015).…”

Section: Eb'ler Dokulardaunclassified

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Endokrin Bozucuların İmmün Sistem ve İnflamasyon Üzerine Etkileri

Onur¹,

Şahin²

2022

Endokrin Bozucular Ve Sağlık

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Endocrine-disrupting chemicals (EDCs) often show their effects through steroid hormones or peptide/protein hormones, and they can disrupt any aspect of hormone activity. It is stated that EDCs not only affect endocrine function, but also negatively affect immune system function. They can affect immune function either directly through the action on immune cell surface receptors or indirectly through other physiological mediators. Exposure to EDCs typically impairs immune functions, either by suppressing immunity and increasing susceptibility to infections, or by enhancing the immune response, leading to inflammation, allergies, or autoimmune diseases. EDC-mediated immunotoxicity is an important human health concern, as long-term immune dysfunction increases the risk of many communicable and non-communicable diseases. The effect of EDCs on the immune system has largely been studied in the context of allergies and autoimmune disorders. It shows that EDC exposure results in an imbalance in oxidative stress, pro-inflammatory and anti-inflammatory immune responses and consequent increase in inflammation. The dose, duration, route of exposure to these toxins, age, sex of the individual, microbiota status, and other environmental conditions (such as stress, diet, or concomitant exposure to other toxic substances) can also change their effects on immunity. In this chapter, the effects of some EDCs on innate and adaptive immune system cells and the development of inflammation are discussed.

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Section: Oksidatif Stres Ve İnflamasyonunclassified

Section: Eb'ler Dokulardaunclassified

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Endokrin Bozucuların İmmün Sistem ve İnflamasyon Üzerine Etkileri

Onur¹,

Şahin²

2022

Endokrin Bozucular Ve Sağlık

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“…Recently, the effects of Endocrine Disrupting Chemicals (EDCs) on human health and the aquatic life have received considerable attention (Reis, Tabei et al 2014). In both cases, exposure to EDCs has been associated with several diseases involving the reproductive (Xin, Susiarjo et al ;Topper, Walker et al 2015;Uzumcu and Zama 2016), immune (Bado-Nilles, Techer et al 2014;Dietert 2015;Teitelbaum, Belpoggi et al 2015;Heindel and Zoeller 2016) and neurological (Rebuli and Patisaul 2016;Rosenfeld 2016) systems. Furthermore, EDCs are ubiquitous since they have been detected in almost all water matrices including treated and untreated wastewaters (Hamid and Eskicioglu 2012;Nie, Qiang et al 2012;Manickum and John 2014;Belhaj, Baccar et al 2015;Komesli, Muz et al 2015), surface waters ( de Vlaming, Biales et al 2007;Jiang, Yan et al 2012;Esteban, Gorga et al 2014), groundwaters (Campbell, Borglin et al 2006;Shi, Hu et al 2013), and even drinking waters (Li, Ying et al 2010;Bach, Dauchy et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Two-Phase Ozonation for the Removal of Estrone, 17β-Estradiol and 17α-Ethinylestradiol in Water Using Ozone-Loaded Decamethylcyclopentasiloxane

Fredj

Novakoski

Tizaoui

et al. 2017

Ozone: Science & Engineering

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Ozonation has been proven effective for the removal of endocrine disrupting chemicals (EDCs) in water. However, conventional ozonation processesare still limited by ozone low solubility and stability in water. These limitations may be overcome by mixing a prior ozoneloaded non-polar solvent with the aqueous solution. This two-phase ozonation process combines Liquid-liquid extraction and Ozonation (LLO). Decamethylcyclopentasiloxane (D5) was chosen as the solvent to be charged with ozone for its non-toxicity, reusability and high ozone solubility. A concurrent LLO column reactor was designed for the simultaneous degradation of three endocrine disrupting chemicals (EDCs) in water: Estrone (E1), 17βestradiol (E2) and 17α-estradiol (EE2). Results showed that 98% of EDCs were removed effectively from a solution initially concentrated at 1 mg L-1. The efficacy of the degradation depends essentially of the column feeding flow rate, the ozone dose and the operating pH. The generation of byproducts during EDCs degradation by LLO was also investigated in this study. For a complete removal of both EDCs and byproducts, the dose of ozone had to be doubled.

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