Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA)

Influence of temperature on thyroid hormone signaling and endocrine disruptor action in Rana (Lithobates) catesbeiana tadpoles

“…The prospect of altering tissue-specific gene expression programs in animals maintained at nonpermissive environmental temperature that would manifest a detectable biological change upon a return to more favorable conditions was examined with IBF and TCS, environmental chemical contaminants known to display disruptive activity towards TH action (Marlatt et al, 2013;Veldhoen et al, 2006aVeldhoen et al, , 2014b. Cultured tail fin from tadpoles exposed in vivo to T 3 and TCS that was maintained in hormoneand EDC-free culture under low environmental temperature demonstrated altered levels of thrb and hsp30 mRNA following a shift to permissive conditions providing clear evidence of an EDC-mediated alteration in the TH response (see Figs.…”

“…We investigated the impact of environmental temperature on TH action as well as the ability of two common water-borne contaminants and known EDCs to alter hormone-induced changes in the tadpole transcriptome. The nonsteroidal anti-inflammatory drug, ibuprofen (IBF) and the antimicrobial agent, triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS) are ubiquitous aquatic micropollutants that have been detected in surface waters worldwide at levels known to alter TH-regulated gene expression and development in R. catesbeiana and Pseudacris regilla tadpoles (Dann and Hontela, 2011;Hinther et al, 2011;Luo et al, 2014;Marlatt et al, 2013;Osachoff et al, 2014;Veldhoen et al, 2006aVeldhoen et al, , 2014b.…”

Effects of triclosan and triclocarban on the growth inhibition, cell viability, genotoxicity and multixenobiotic resistance responses of Tetrahymena thermophila

“…In addition to the acute toxicity testing, other studies about adverse effects of TCS and TCC (especially for TCS) on aquatic organisms mainly focused on the reproductive and developmental toxicity (Hwang et al, 2014;Marlatt et al, 2013), bioconcentration (Bedoux et al, 2012), or behavior disruptions (Fritsch et al, 2013;Schultz et al, 2012) and enzymes activity changes in detoxification and antioxidant systems (Hinther et al, 2011;Ku et al, 2014;Peng et al, 2013). Unfortunately, the profound toxic action mechanisms/pathways of TCS and TCC to aquatic organisms are still unclear and limited, particularly for the exposure of TCS and TCC at environmental concentrations.…”

P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats

“…In recent years, more studies have demonstrated that the thyroid is vulnerable to triclosan exposure, and triclosan could influence thyroid functions and lead to hypothyroidism in mammalian models [5-7]. Triclosan has also been shown to interfere with the thyroid axis in zebrafish [8] and frogs [9]. …”