Trichoscopy pattern and evaluation of serum vitamin D status in alopecia areata

Alsenaid, Adel; Alhetheli, Ghadah; AbdElneam, Ahmed Ibrahim; Al‐Dhubaibi, Mohammed Saleh

doi:10.1016/j.pdpdt.2023.103510

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2024

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“…1 ). Notably, the latter two are frequently recognized as early indicators of AA activity (Alsenaid et al 2023 ). Furthermore, they serve as markers of either existing or impending hair breakage in the context of AA.…”

Section: Introductionmentioning

confidence: 99%

Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis

Xu,

Xie,

Wei

et al. 2024

Amino Acids

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In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the underlying etiology precipitating this hair breakage remains largely uncharted territory. Our exhaustive review of the existing literature points to a pivotal role for cysteine—a key amino acid central to hair growth—in these mechanisms. This review will probe and deliberate upon the implications of aberrant cysteine metabolism in the pathogenesis of AA. It will examine the potential intersections of cysteine metabolism with autophagy, ferroptosis, immunity, and psychiatric manifestations associated with AA. Such exploration could illuminate new facets of the disease's pathophysiology, potentially paving the way for innovative therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%