Dissecting hair breakage in alopecia areata: the central role of dysregulated cysteine homeostasis
Wen Xu,
Bo Xie,
Dongfan Wei
et al.
Abstract:In the initial stages of Alopecia Areata (AA), the predominance of hair breakage or exclamation mark hairs serves as vital indicators of disease activity. These signs are non-invasive and are commonly employed in dermatoscopic examinations. Despite their clinical salience, the underlying etiology precipitating this hair breakage remains largely uncharted territory. Our exhaustive review of the existing literature points to a pivotal role for cysteine—a key amino acid central to hair growth—in these mechanisms.… Show more
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